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A report on the use of a single intra-articular administration of autologous platelet therapy in a naturally occurring canine osteoarthritis model : a preliminary study

2020-02-27Journal article Open access
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dc.contributor.authorAlves, João C.
dc.contributor.authorSantos, A.
dc.contributor.authorJorge, P.
dc.contributor.authorLavrador, C.
dc.contributor.authorCarreira, L.Miguel
dc.date.accessioned2022-04-14T16:47:44Z
dc.date.available2022-04-14T16:47:44Z
dc.date.issued2020-02-27
dc.descriptionResearch Areas : Orthopedics ; Rheumatologypt_PT
dc.description.abstractBackground: Osteoarthritis (OA) represents a significant burden to societies, as it affects quality of life, performance and poses a large healthcare cost. We aimed to describe the use of a single intra-articular (IA) injection of an autologous platelet therapy in the management of osteoarthritis (OA) in a naturally occurring canine model. Methods: Fifteen police working dogs with bilateral hip OA were treated with 3 ml of platelet concentrate per hip joint, produced with the V-PET kit. Response to treatment was measured by the Canine Brief Pain Inventory (CBPI, divided in pain interference score – PIS, and Pain Severity Score - PSS), Liverpool Osteoarthritis in Dogs (LOAD), Canine Orthopedic Index (COI, divided in four dimensions: function, gait, stiffness and quality of life - QOL) and the Hudson Visual Analogue Scale (HVAS). Seven different time points were considered: T0 (before treatment), T1 (after 15 days), T2, T3, T4, T5 and T6 (after 1, 2, 3, 4 and 5 months respectively). Results from each evaluation moment were compared with T0 with a Paired Samples T-Test, and a p < 0.05 was set. Results: Significant differences were observed at T1 (p < 0.01 for HVAS, PSS, COI, Gait and QOL; p = 0.01 for PIS; p = 0.02 for Function; and p < 0.05 for Stiffness), T2 (p < 0.01 for PSS, PIS and Gait; p = 0.01 for COI; p = 0.02 for HVAS, Function and QOL; and p = 0.04 for Stiffness), T3 (p < 0.01 for HVAS, PSS, PIS, Function and Gait; p = 0.01 for COI; and p = 0.02 for QOL), T4 (p < 0.01 for PSS; p = 0.03 for PIS and Gait), T5 (p < 0.01 for COI, Function and Gait; p = 0.03 for PSS, PIS and Stiffness), T6 (p < 0.01 for PSS, Function and Gait; p = 0.04 for PIS; p < 0.05 for COI) and T7 (p < 0.01 for PSS, Function and Gait; p = 0.01 for COI; and p < 0.05 for PIS). Conclusions: Autologous platelet therapy was used without apparent harm in the subjects. A single administration produced significant improvements, which lasted several months, and therefore warrants further study.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves JC, Santos A, Jorge P, Lavrador C, Carreira LM. 2020. A report on the use of a single intra-articular administration of autologous platelet therapy in a naturally occurring canine osteoarthritis model : a preliminary study. BMC Musculoskeletal Disorders, 21(1):127. Doi 10.1186/s12891-020-3140-9pt_PT
dc.identifier.doi10.1186/s12891-020-3140-9pt_PT
dc.identifier.eissn1471-2474
dc.identifier.urihttp://hdl.handle.net/10400.5/24081
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relation.publisherversionhttps://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-020-3140-9pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimal modelpt_PT
dc.subjectDogpt_PT
dc.subjectOsteoarthritispt_PT
dc.subjectPainpt_PT
dc.subjectAutologous platelet concentratept_PT
dc.subjectClinical metrology instrumentspt_PT
dc.titleA report on the use of a single intra-articular administration of autologous platelet therapy in a naturally occurring canine osteoarthritis model : a preliminary studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceLondon, Englandpt_PT
oaire.citation.titleBMC Musculoskeletal Disorderspt_PT
oaire.citation.volume21(1):127pt_PT
person.familyNameCarreira
person.givenNameLuis Miguel
person.identifier.ciencia-idFD14-B321-EACD
person.identifier.orcid0000-0002-6784-2806
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3757a9f0-ab19-4225-bd5d-d68d19ec743a
relation.isAuthorOfPublication.latestForDiscovery3757a9f0-ab19-4225-bd5d-d68d19ec743a

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