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BRAF L597K mutation: an opportunity to treat

2021Artigo científico Acesso aberto
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dc.contributor.authorLobo-Martins, Soraia
dc.contributor.authorPais, Helena Luna
dc.contributor.authorSoares-de-Almeida, Luís
dc.contributor.authorCosta, Luis
dc.contributor.authorMansinho, André
dc.contributor.authorSousa, Rita Teixeira de
dc.date.accessioned2022-09-29T14:35:04Z
dc.date.available2022-09-29T14:35:04Z
dc.date.issued2021
dc.description© Copyright 2021 by the author(s).This work is made available under the terms of a Creative Commons Attribution-NonCommercial-NoDerivatives License, available at https://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.description.abstractThe outcomes of patients with metastatic melanoma (MM) have significantly improved after the introduction of BRAF-specific inhibitors. Herein is reported a patient with MM and non-V600-BRAF mutation who responded to iBRAF/iMEK therapy. In July 2014, a 63-year-old man presented with a 4.1mm-thick V600E-BRAF wild type melanoma on the back. Metastases were identified in one sentinel node and two of 11 subsequently excised lymph nodes, with no signs of distant metastatic disease. In September 2017, lung metastasis was observed and pembrolizumab was started. Progressive disease was apparent at cycle 10 and therapy was switched to ipilimumab. After four cycles, an asymmetric response was observed. In November 2017, next generation sequencing genomic profiling disclosed a rare L597K-BRAF mutation and vemurafenib plus cobimetinib therapy was initiated in January 2018. Seven days after treatment start, a remarkable clinical improvement was observed. In April 2018, the patient achieved partial response, which was sustained until October 2018. Cases of patients with non-V600-BRAF mutations responding to iBRAF/iMEK therapy have been reported over the last years. To the best of our knowledge, this is the first case reporting response to combined iBRAF/iMEK therapy in a patient with metastatic melanoma harboring L597K mutation.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDermatol Online J. 2021 Jan 15;27(1):13030/qt18k3573spt_PT
dc.identifier.doi10.5070/D3271052029pt_PT
dc.identifier.eissn1087-2108
dc.identifier.urihttp://hdl.handle.net/10451/54631
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publishereScholarship Publishingpt_PT
dc.relation.publisherversionhttps://escholarship.org/uc/dojpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMetastatic melanomapt_PT
dc.subjectNon-V600 BRAF mutationpt_PT
dc.subjectTarget therapypt_PT
dc.titleBRAF L597K mutation: an opportunity to treatpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleDermatology Online Journalpt_PT
oaire.citation.volume27pt_PT
person.familyNameLobo-Martins
person.familyNameSoares-de-Almeida
person.familyNameCosta
person.familyNameMansinho
person.familyNameTeixeira de Sousa
person.givenNameSoraia
person.givenNameLuis
person.givenNameLuis
person.givenNameAndré
person.givenNameRita
person.identifier.ciencia-idEA1E-AC1F-8A4E
person.identifier.ciencia-id691E-9432-01C0
person.identifier.ciencia-id041E-4ADE-FB64
person.identifier.ciencia-id7614-C999-F6C7
person.identifier.ciencia-idA81D-84E4-6399
person.identifier.orcid0000-0001-5847-7192
person.identifier.orcid0000-0003-4026-6105
person.identifier.orcid0000-0002-4782-7318
person.identifier.orcid0000-0001-8771-0838
person.identifier.orcid0000-0002-9147-7896
person.identifier.ridJ-8716-2012
person.identifier.scopus-author-id6507304614
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication72939d9d-287f-4145-be48-cd3f338d7913
relation.isAuthorOfPublication3e7d32f0-5127-4946-8301-681e1c650d4c
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relation.isAuthorOfPublicationa49dddc2-aab9-467c-b47f-485a1cde5883
relation.isAuthorOfPublication.latestForDiscovery72939d9d-287f-4145-be48-cd3f338d7913

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