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Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Review

2022-09-21Artigo científico Acesso aberto
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dc.contributor.authorRolo, Dora
dc.contributor.authorAssunção, Ricardo
dc.contributor.authorVentura, Célia
dc.contributor.authorAlvito, Paula
dc.contributor.authorGonçalves, Lídia
dc.contributor.authorMartins, Carla
dc.contributor.authorBettencourt, Ana
dc.contributor.authorJordan, Peter
dc.contributor.authorVital, Nádia
dc.contributor.authorPereira, Joana
dc.contributor.authorPinto, Fátima
dc.contributor.authorMatos, Paulo
dc.contributor.authorSilva, Maria João
dc.contributor.authorLouro, Henriqueta
dc.date.accessioned2023-09-11T16:38:36Z
dc.date.available2023-09-11T16:38:36Z
dc.date.issued2022-09-21
dc.date.updated2023-02-27T14:52:18Z
dc.description.abstractTitanium dioxide nanoparticles (TiO2-NPs) are widely used, and humans are exposed through food (E171), cosmetics (e.g., toothpaste), and pharmaceuticals. The oral and gastrointestinal (GIT) tract are the first contact sites, but it may be systemically distributed. However, a robust adverse outcome pathway (AOP) has not been developed upon GIT exposure to TiO2-NPs. The aim of this review was to provide an integrative analysis of the published data on cellular and molecular mechanisms triggered after the ingestion of TiO2-NPs, proposing plausible AOPs that may drive policy decisions. A systematic review according to Prisma Methodology was performed in three databases of peer-reviewed literature: Pubmed, Scopus, and Web of Science. A total of 787 records were identified, screened in title/abstract, being 185 used for data extraction. The main endpoints identified were oxidative stress, cytotoxicity/apoptosis/cell death, inflammation, cellular and systemic uptake, genotoxicity, and carcinogenicity. From the results, AOPs were proposed where colorectal cancer, liver injury, reproductive toxicity, cardiac and kidney damage, as well as hematological effects stand out as possible adverse outcomes. The recent transgenerational studies also point to concerns with regard to population effects. Overall, the findings further support a limitation of the use of TiO2-NPs in food, announced by the European Food Safety Authority (EFSA).pt_PT
dc.description.sponsorshipThis research was funded by the Portuguese Foundation for Science and Technology FCT/MCTES through national funds (PIDDAC), PTDC/SAU-PUB/29481/2017 and co-funded by UIDB/00009/2020 (Centre for Toxicogenomics and Human Health—ToxOmics (UIDP/00009/2020; UIDB/00009/2020), iMed.ULisboa (UIDB/04138/2020+UIDP/04138/2020), CESAM (UIDP/50017/2020+UIDB/50017/2020+LA/P/0094/2020), and BioISI (UID/MULTI/04046/2019). N.V. thanks the Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia, e Ensino Superior, for her PhD grant 2020.07168.BD. L.G. was supported by FCT Individual CEEC as a Principal Researcher Grant (CEECIND/03143/2017) and R.A. as an Assistant Researcher Grant (CEECIND/01570/2018).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRolo D, Assunção R, Ventura C, Alvito P, Gonçalves L, Martins C, et al. Adverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles—A Systematic Review. Nanomaterials [Internet]. 2022 Sep 21;12(19):3275. Available from: http://dx.doi.org/10.3390/nano12193275pt_PT
dc.identifier.doi10.3390/nano12193275pt_PT
dc.identifier.slugcv-prod-3147551
dc.identifier.urihttp://hdl.handle.net/10451/59208
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUIDB/00009/2020pt_PT
dc.relationUIDB/04138/2020pt_PT
dc.relationCentre for Toxicogenomics and Human Health
dc.relationUIDP/50017/2020pt_PT
dc.relationUIDB/50017/2020pt_PT
dc.relationLA/P/0094/2020pt_PT
dc.relationUID/MULTI/04046/2019pt_PT
dc.relation2020.07168.BDpt_PT
dc.relationCEECIND/03143/2017pt_PT
dc.relationCEECIND/01570/2018pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2079-4991/12/19/3275pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjecttitanium dioxide nanoparticlespt_PT
dc.subjecthuman exposurept_PT
dc.subjectingested TIO2-NPspt_PT
dc.subjectAOPpt_PT
dc.subjectnanosafetypt_PT
dc.subjectcolorectal cancerpt_PT
dc.subjectadverse outcomespt_PT
dc.titleAdverse Outcome Pathways Associated with the Ingestion of Titanium Dioxide Nanoparticles A Systematic Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/SAU-PUB/29481/2017
oaire.awardNumberUIDP/00009/2020
oaire.awardTitleCentre for Toxicogenomics and Human Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-PUB%2F29481%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00009%2F2020/PT
oaire.citation.issue19pt_PT
oaire.citation.startPage3275pt_PT
oaire.citation.titleNanomaterialspt_PT
oaire.citation.volume12pt_PT
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oaire.fundingStream6817 - DCRRNI ID
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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