Orientador(es)
Resumo(s)
The new macrocyclic lathyrane diterpenes latilagascenes A and B (1 and 2), the diacetylated derivative of 2, latilagascene C (3), and the known diterpenes ent- 16 alpha,17-dihydroxyatisan-3-one (4) and ent-16 alpha,17-dihydroxykauran-3-one (5), isolated from the methanol extract of Euphorbia lagascae, were examined for their effects on the reversal of multidrug resistance (MDR) oil mouse lymphoma cells. Among the active lathyrane derivatives 1 -3, compound 2 displayed the highest inhibition of rhodamine 123 efflux of human MDR gene transfected Mouse lymphoma cells when compared to the untreated cells or the positive control verapamil. The new compounds are the first macrocyclic lathyrane diterpenes showing oxidation at C-16, whose structures were characterized by extensive spectroscopic methods, including 2D NMR experiments (H-1-H-1 COSY, HMQC, HMBC and NOESY). The known phenolic Compounds vanillic acid (6), p-salicylic acid (7), isofraxidin (8) and cleomiscosin A (9) were also isolated from this species.
Descrição
Palavras-chave
Plant Sciences Chemistry, Medicinal Pharmacology & Pharmacy
Contexto Educativo
Citação
PLANTA MEDICA. - Vol. 72, n. 2 (FEB 2006), p. 162-168
Editora
GEORG THIEME VERLAG KG