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Serotypes 1, 7F and 19A became the leading causes of pediatric invasive pneumococcal infections in Portugal after 7 years of heptavalent conjugate vaccine use
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Orientador(es)
Resumo(s)
We characterized 353 isolates responsible for pediatric invasive pneumococcal infections (IPD) in Portugal
between 2006 and 2008. Serotypes included in the seven-valent conjugate vaccine (PCV7) accounted
for 17% of IPD. Serotypes 1, 7F and 19A were the most frequent causes of IPD and the later consolidated as
the most frequent serotype among erythromycin and penicillin non-susceptible isolates. Serotype 1 was
associated with older children and empyemas, while serotype 19A was associated with IPD in younger
(<2 years) children. The higher valency vaccines PCV10 and PCV13 have a potentially superior coverage,
55% and 83% respectively, but non-vaccine serotypes are emerging as important causes of IPD. A
decline of resistance with patient age was noted. Comparing with previous data from Portugal, this study
showed a continued decline of PCV7 serotypes and that overall resistance has stabilized following the
initial decline of the first post-PCV7 years.
Descrição
© 2010 Elsevier Ltd. All rights reserved.
Palavras-chave
Streptococcus pneumoniae Conjugate vaccines Antimicrobial resistance Pediatrics
Contexto Educativo
Citação
Vaccine 28 (2010) 5167–5173