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Co-transcriptional splicing and the CTD code

2016-09Artigo científico Acesso restrito
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dc.contributor.authorCustódio, Noélia
dc.contributor.authorCarmo-Fonseca, Maria
dc.date.accessioned2021-07-19T13:24:45Z
dc.date.available2021-07-19T13:24:45Z
dc.date.issued2016-09
dc.description© 2016 Informa UK Limited, trading as Taylor & Francis Group.pt_PT
dc.description.abstractTranscription and splicing are fundamental steps in gene expression. These processes have been studied intensively over the past four decades, and very recent findings are challenging some of the formerly established ideas. In particular, splicing was shown to occur much faster than previously thought, with the first spliced products observed as soon as splice junctions emerge from RNA polymerase II (Pol II). Splicing was also found coupled to a specific phosphorylation pattern of Pol II carboxyl-terminal domain (CTD), suggesting a new layer of complexity in the CTD code. Moreover, phosphorylation of the CTD may be scarcer than expected, and other post-translational modifications of the CTD are emerging with unanticipated roles in gene expression regulation.pt_PT
dc.description.sponsorshipAuthors acknowledge support from Fundação para a Ciência e a Tecnologia, 10.13039/501100001871 [FCT-ANR/BIM-ONC/0009/2013]pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCrit Rev Biochem Mol Biol. 2016 Sep;51(5):395-411pt_PT
dc.identifier.doi10.1080/10409238.2016.1230086pt_PT
dc.identifier.eissn1549-7798
dc.identifier.issn1040-9238
dc.identifier.urihttp://hdl.handle.net/10451/48999
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherInforma UKpt_PT
dc.relationEpigenetics and alternative splicing: role in immune T cell differentiation and leukemogenesis
dc.relation.publisherversionhttps://www.tandfonline.com/toc/ibmg20/currentpt_PT
dc.subjectCTD codept_PT
dc.subjectRNA Polymerase IIpt_PT
dc.subjectSpliceosomept_PT
dc.subjectSplicingpt_PT
dc.subjectTranscriptionpt_PT
dc.titleCo-transcriptional splicing and the CTD codept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEpigenetics and alternative splicing: role in immune T cell differentiation and leukemogenesis
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/FCT-ANR%2FBIM-ONC%2F0009%2F2013/PT
oaire.citation.endPage411pt_PT
oaire.citation.issue5pt_PT
oaire.citation.titleCritical Reviews in Biochemistry and Molecular Biologypt_PT
oaire.citation.volume51pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameFernandes Custódio
person.familyNameCarmo-Fonseca
person.givenNameNoélia Maria
person.givenNameMaria
person.identifier.ciencia-id8615-44B3-7645
person.identifier.ciencia-idB31F-0435-0753
person.identifier.orcid0000-0001-9230-9870
person.identifier.orcid0000-0002-3402-7143
person.identifier.scopus-author-id6508187568
person.identifier.scopus-author-id7007128195
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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