Publication
IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner
| dc.contributor.author | Azevedo, R. I. | |
| dc.contributor.author | Soares, M. V. | |
| dc.contributor.author | Barata, J. T. | |
| dc.contributor.author | Tendeiro, R. | |
| dc.contributor.author | Serra-Caetano, A. | |
| dc.contributor.author | Victorino, R. M. | |
| dc.contributor.author | Sousa, A. E. | |
| dc.date.accessioned | 2015-02-03T16:02:11Z | |
| dc.date.available | 2015-02-03T16:02:11Z | |
| dc.date.issued | 2008 | |
| dc.description | © 2009 by The American Society of Hematology | por |
| dc.description.abstract | The CD31(+) subset of human naive CD4(+) T cells is thought to contain the population of cells that have recently emigrated from the thymus, while their CD31(-) counterparts have been proposed to originate from CD31(+) cells after homeostatic cell division. Naive T-cell maintenance is known to involve homeostatic cytokines such as interleukin-7 (IL-7). It remains to be investigated what role this cytokine has in the homeostasis of naive CD4(+) T-cell subsets defined by CD31 expression. We provide evidence that IL-7 exerts a preferential proliferative effect on CD31(+) naive CD4(+) T cells from adult peripheral blood compared with the CD31(-) subset. IL-7-driven proliferation did not result in loss of CD31 expression, suggesting that CD31(+) naive CD4(+) T cells can undergo cytokine-driven homeostatic proliferation while preserving CD31. Furthermore, IL-7 sustained or increased CD31 expression even in nonproliferating cells. Both proliferation and CD31 maintenance were dependent on the activation of phosphoinositide 3-kinase (PI3K) signaling. Taken together, our data suggest that during adulthood CD31(+) naive CD4(+) T cells are maintained by IL-7 and that IL-7-based therapies may exert a preferential effect on this population. | por |
| dc.description.sponsorship | This work was supported by grant POCI/BIA-BCM/61079/2004 from Fundação para a Ciência e a Tecnologia (FCT) and by Programa Operacional Ciência e Inovação 2010 (POCI2010; to M.V.D.S.) R.I.A., M.V.D.S., and R.T. received scholarships from FCT cofinanced by POCI 2010 and FSE. | por |
| dc.identifier.citation | Blood, 26 March 2009, Volume 113, Number 13 | por |
| dc.identifier.issn | 0006-4971 | |
| dc.identifier.uri | http://dx.doi.org/10.1182/blood-2008-07-166223 | |
| dc.identifier.uri | http://hdl.handle.net/10451/15874 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | American Society of Hematology | por |
| dc.relation.publisherversion | The definitive version is available at http://www.bloodjournal.org/ | por |
| dc.title | IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/POCI/POCI%2FBIA-BCM%2F61079%2F2004/PT | |
| oaire.citation.title | Blood | por |
| oaire.fundingStream | POCI | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | closedAccess | por |
| rcaap.type | article | por |
| relation.isProjectOfPublication | 97013015-4d59-4ff6-b9ba-2d1b16ce7242 | |
| relation.isProjectOfPublication.latestForDiscovery | 97013015-4d59-4ff6-b9ba-2d1b16ce7242 |