High genetic diversity of human immunodeficiency virus type 1 in Angola

Bártolo, Inês; Epalanga, Marta; Bartolomeu, José; Fonseca, Marlene; Mendes, Ana; Gama, António; Taveira, Nuno

http://hdl.handle.net/10400.5/102928

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Abstract(s)

To investigate which HIV-1 genetic forms are circulating in Angola, we have determined the gag and/or env genotypes of 48 isolates from patients living in Cabinda and Luanda provinces. The following subtypes were identified: A1 (18 samples, 38%), C (7, 15%), H (5, 10%), J (3, 6%), G (2, 4%), A2 (2, 4%), F1 (1, 2%), and D (1, 2%). The env gene fragment was untypable in one sample. Discordant subtype classifications in the gag and env genes were found in eight (17%) samples. There were six different recombination patterns (gag/env): A1/H (3, 6%), A1/G (1, 2%), C/A2 (1, 2%), F1/B (1, 2%), G/B (1, 2%), and G/H (1, 2%). The A1/H recombinant may represent a new circulating recombinant form. The marked genetic heterogeneity of HIV-1 in Angola has important implications for vaccine development.

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http://hdl.handle.net/10400.5/102928

Citation

Bártolo I, Epalanga M, Bartolomeu J, Fonseca M, Mendes A, Gama A, et al. High Genetic Diversity of Human Immunodeficiency Virus Type 1 in Angola. AIDS Research and Human Retroviruses 2005;21:306–10. https://doi.org/10.1089/aid.2005.21.306.