Logo do repositório
 
Publicação

3D-printed platform multi-loaded with bioactive, magnetic nanoparticles and an antibiotic for re-growing bone tissue

2021-01Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorSaraiva, Ana S.
dc.contributor.authorRibeiro, Isabel A. C.
dc.contributor.authorFernandes, Maria H.
dc.contributor.authorCerdeira, Ana Cláudia
dc.contributor.authorVieira, Bruno J.C.
dc.contributor.authorWaerenborgh, João Carlos
dc.contributor.authorPereira, Laura C.J.
dc.contributor.authorCláudio, Ricardo
dc.contributor.authorCarmezim, Maria João
dc.contributor.authorGomes, Pedro
dc.contributor.authorGonçalves, Lídia
dc.contributor.authorSantos, Catarina F.
dc.contributor.authorBettencourt, Ana
dc.date.accessioned2024-01-23T16:00:28Z
dc.date.available2024-01-23T16:00:28Z
dc.date.issued2021-01
dc.date.updated2023-02-27T16:10:53Z
dc.description.abstractPolymeric platforms obtained by three-dimensional (3D) printing are becoming increasingly important as multifunctional therapeutic systems for bone treatment applications. In particularly, researchers aim to control bacterial biofilm on these 3D-platforms and enhance re-growing bone tissue, at the same time. This study aimed to fabricate a 3D-printed polylactic acid platform loaded with hydroxyapatite (HA), iron oxide nanoparticles (IONPs) and an antibiotic (minocycline) with tuneable properties and multistimuli response. IONPs were produced by a facile chemical co-precipitation method showing an average diameter between 11 and 15 nm and a superparamagnetic behaviour which was preserved when loaded into the 3D-platforms. The presence of two types of nanoparticles (IONPs and HA) modify the nanomorphological/nanotopographical feature of the 3D-platforms justifying their adequate bioactivity profile and in vitro cellular effects on immortalized and primary osteoblasts, including cytocompatibility and increased osteogenesis-related gene expression (RUNX2, BGLAP and SPP1). Disk diffusion assays and SEM analysis confirmed the effect of the 3D-platforms loaded with minocycline against Staphylococcus aureus. Altogether results showed that fabricated 3D-platforms combined the exact therapeutic antibiofilm dose of the antibiotic against S. aureus, with the enhanced osteogenic stimulation of the HA and IONPs nanoparticles which is a disruptive approach for bone targeting applications.pt_PT
dc.description.sponsorshipSupport for this work was provided by National Funds through FCT - Fundação para a Ciência e Tecnologia, I.P, under the projects with references UIDB/04138/2020 and UIDP/04138/2020, PTDC/BTM-SAL/29335/2017, UIDB/50022/2020, CQE-UIDB/00100/2020, UIDB/50006/2020, UID/Multi/04349/2013, PDTC/QUI-QIN/32240/2017 and GCT grant to A.C.C. (BL156/2019_IST-ID).pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationSaraiva AS, Ribeiro IAC, Fernandes MH, Cerdeira AC, Vieira BJC, Waerenborgh JC, et al. 3D-printed platform multi-loaded with bioactive, magnetic nanoparticles and an antibiotic for re-growing bone tissue. International Journal of Pharmaceutics [Internet]. janeiro de 2021;593:120097. Disponível em: https://linkinghub.elsevier.com/retrieve/pii/S0378517320310826pt_PT
dc.identifier.doi10.1016/j.ijpharm.2020.120097pt_PT
dc.identifier.issn0378-5173
dc.identifier.slugcv-prod-2118917
dc.identifier.urihttp://hdl.handle.net/10451/62047
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPDTC/QUI-QIN/32240/2017pt_PT
dc.relationResearch Institute for Medicines
dc.relationResearch Institute for Medicines
dc.relationAntiBiofilm features of Glycolipid-functionalized Silicone Catheters towards Healthcare-associated infections prevention
dc.relationAssociate Laboratory of Energy, Transports and Aeronautics
dc.relationCentro de Química Estrutural
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationCentre for Nuclear Sciences and Technologies
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0378517320310826pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPolylactic acid 3D-platformpt_PT
dc.subjectiron oxide nanoparticlespt_PT
dc.subjectsuperparamagneticpt_PT
dc.subjectnanohydroxyapatitept_PT
dc.subjectantibacterialpt_PT
dc.subjectbone regenerationpt_PT
dc.title3D-printed platform multi-loaded with bioactive, magnetic nanoparticles and an antibiotic for re-growing bone tissuept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleAntiBiofilm features of Glycolipid-functionalized Silicone Catheters towards Healthcare-associated infections prevention
oaire.awardTitleAssociate Laboratory of Energy, Transports and Aeronautics
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleCentre for Nuclear Sciences and Technologies
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBTM-SAL%2F29335%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50022%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04349%2F2013/PT
oaire.citation.startPage120097pt_PT
oaire.citation.titleInternational Journal of Pharmaceuticspt_PT
oaire.citation.volume593pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameRibeiro
person.familyNameDiogo Gonçalves
person.familyNameCampos Simão Bettencourt
person.givenNameIsabel
person.givenNameLídia Maria
person.givenNameAna Francisca
person.identifier163977
person.identifierM-4219-2013
person.identifier.ciencia-idE31A-26B8-4AC6
person.identifier.ciencia-id7211-22BA-86AD
person.identifier.ciencia-id7C1F-F932-33DC
person.identifier.orcid0000-0002-7110-6393
person.identifier.orcid0000-0002-6799-2740
person.identifier.orcid0000-0002-8498-5892
person.identifier.ridA-6098-2014
person.identifier.scopus-author-id22836446000
person.identifier.scopus-author-id6603687672
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid7211-22BA-86AD | Lídia Maria Diogo Gonçalves
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb15ae5e0-4a4c-4d0a-b2d2-db5e91f65ec0
relation.isAuthorOfPublication3265148d-dc2d-4601-a832-2e72f7be5662
relation.isAuthorOfPublication9068061a-d0cf-433b-a6ca-598031d0645a
relation.isAuthorOfPublication.latestForDiscovery9068061a-d0cf-433b-a6ca-598031d0645a
relation.isProjectOfPublicationbb00962c-ed82-4d7a-bc37-61df49767d93
relation.isProjectOfPublicationa21e6964-b01b-421e-9356-1ff6579cdd5c
relation.isProjectOfPublication5966fca9-23aa-45cd-aed7-d37a624e0637
relation.isProjectOfPublicationae5c2fca-85f7-4b6c-8585-b51215d539a3
relation.isProjectOfPublication6f563b11-7a3d-4ed6-9d77-235805ada8d4
relation.isProjectOfPublicationbe39fa48-21c8-44d1-bb97-d740294ed742
relation.isProjectOfPublicationf466786c-bc57-4dea-9e91-af46d9d86d93
relation.isProjectOfPublication.latestForDiscovery5966fca9-23aa-45cd-aed7-d37a624e0637

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
saraiva2020.pdf
Tamanho:
5.72 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.2 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

FF - CiênciaVitae - Faculdade de Farmácia