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Effect Biomarkers of the Widespread Antimicrobial Triclosan in a Marine Model Diatom

2022-07Journal article Open access
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dc.contributor.authorDuarte, Bernardo
dc.contributor.authorFeijão, Eduardo
dc.contributor.authorCruz De Carvalho, Ricardo
dc.contributor.authorMatos, Ana Rita
dc.contributor.authorCabrita, Maria Teresa
dc.contributor.authorNovais, Sara C.
dc.contributor.authorMoutinho, Ariana
dc.contributor.authorLemos, Marco F. L.
dc.contributor.authorMarques, João Carlos
dc.contributor.authorCaçador, Isabel
dc.contributor.authorReis-Santos, Patrick
dc.contributor.authorFonseca, Vanessa F.
dc.date.accessioned2023-01-09T18:57:30Z
dc.date.available2023-01-09T18:57:30Z
dc.date.issued2022-07
dc.description.abstractThe present-day COVID-19 pandemic has led to the increasing daily use of antimicrobials worldwide. Triclosan is a manmade disinfectant chemical used in several consumer healthcare products, and thus frequently detected in surface waters. In the present work, we aimed to evaluate the effect of triclosan on diatom cell photophysiology, fatty acid profiles, and oxidative stress biomarkers, using the diatom Phaeodactylum tricornutum as a model organism. Several photochemical effects were observed, such as the lower ability of the photosystems to efficiently trap light energy. A severe depletion of fucoxanthin under triclosan application was also evident, pointing to potential use of carotenoid as reactive oxygen species scavengers. It was also observed an evident favouring of the peroxidase activity to detriment of the SOD activity, indicating that superoxide anion is not efficiently metabolized. High triclosan exposure induced high cellular energy allocation, directly linked with an increase in the energy assigned to vital functions, enabling cells to maintain the growth rates upon triclosan exposure. Oxidative stress traits were found to be the most efficient biomarkers as promising tools for triclosan ecotoxicological assessments. Overall, the increasing use of triclosan will lead to significant effects on the diatom photochemical and oxidative stress levels, compromising key roles of diatoms in the marine system.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDuarte, B.; Feijão, E.; Cruz de Carvalho, R.; Matos, A.R.; Cabrita, M.T.; Novais, S.C.; Moutinho, A.; Lemos, M.F.L.; Marques, J.C.; Caçador, I.; Reis-Santos, P.; Fonseca, V.F. Effect Biomarkers of the Widespread Antimicrobial Triclosan in a Marine Model Diatom. Antioxidants 2022, 11, 1442. https://doi.org/10.3390/antiox11081442pt_PT
dc.identifier.doi10.3390/antiox11081442pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/55763
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFCT UIDB/04292/2020pt_PT
dc.relationSR&TD SmartBioR (reference Centro-01-0145-FEDER-000018), co-funded by Centro 2020 program, Portugal 2020, European Union, through the European Regional Development Fundpt_PT
dc.relationFCT CEECIND/00511/2017pt_PT
dc.relationFCT UIDP/04292/2020pt_PT
dc.relationFCT LA/P/0069/2020pt_PT
dc.relationFCT UID/MULTI/04046/2019pt_PT
dc.relationFCT PTDC/CTA-AMB/30056/2017pt_PT
dc.relationFCT 2021.00244.CEECINDpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleEffect Biomarkers of the Widespread Antimicrobial Triclosan in a Marine Model Diatompt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue8pt_PT
oaire.citation.startPage1442pt_PT
oaire.citation.titleAntioxidantspt_PT
oaire.citation.volume11pt_PT
person.familyNameCruz de Carvalho
person.givenNameRicardo
person.identifier442818
person.identifier.ciencia-id311B-E5EE-6CD7
person.identifier.orcid0000-0003-4612-9013
person.identifier.ridB-1091-2009
person.identifier.scopus-author-id55365227900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication5252acf8-8578-4089-bf97-e5736043eb67
relation.isAuthorOfPublication.latestForDiscovery5252acf8-8578-4089-bf97-e5736043eb67

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