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Impairment of episodic memory in genetic frontotemporal dementia : a GENFI study

2021Artigo científico Acesso aberto
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dc.contributor.authorPoos, Jackie M.
dc.contributor.authorRussell, Lucy L.
dc.contributor.authorPeakman, Georgia
dc.contributor.authorBocchetta, Martina
dc.contributor.authorGreaves, Caroline V.
dc.contributor.authorJiskoot, Lize C.
dc.contributor.authorEnde, Emma L.
dc.contributor.authorSeelaar, Harro
dc.contributor.authorPapma, Janne M.
dc.contributor.authorden Berg, Esther
dc.contributor.authorPijnenburg, Yolande A.L.
dc.contributor.authorBruffaerts, Rose
dc.contributor.authorVandamme, Philip
dc.contributor.authorVandenbulcke, Mathieu
dc.contributor.authorFerreira, Catarina B.
dc.contributor.authorMiltenberger-Miltenyi, Gabriel
dc.contributor.authorMaruta, Carolina
dc.contributor.authorVerdelho, Ana
dc.contributor.authorAfonso, Sónia
dc.contributor.authorTaipa, Ricardo
dc.contributor.authorCaroppo, Paola
dc.contributor.authorBorroni, Barbara
dc.contributor.authorDi Fede, Giuseppe
dc.contributor.authorGiaccone, Giorgio
dc.contributor.authorPrioni, Sara
dc.contributor.authorRedaelli, Veronica
dc.contributor.authorRossi, Giacomina
dc.contributor.authorTiraboschi, Pietro
dc.contributor.authorDuro, Diana
dc.contributor.authorAlmeida, Maria Rosario
dc.contributor.authorCastelo‐Branco, Miguel
dc.contributor.authorLeitão, Maria João
dc.contributor.authorSanchez‐Valle, Raquel
dc.contributor.authorTabuas‐Pereira, Miguel
dc.contributor.authorSantiago, Beatriz
dc.contributor.authorGauthier, Serge
dc.contributor.authorRosa‐Neto, Pedro
dc.contributor.authorVeldsman, Michele
dc.contributor.authorThompson, Paul
dc.contributor.authorLangheinrich, Tobias
dc.contributor.authorPrix, Catharina
dc.contributor.authorHoegen, Tobias
dc.contributor.authorWlasich, Elisabeth
dc.contributor.authorMoreno, Fermin
dc.contributor.authorLoosli, Sandra
dc.contributor.authorSchonecker, Sonja
dc.contributor.authorAnderl‐Straub, Sarah
dc.contributor.authorLombardi, Jolina
dc.contributor.authorBargalló, Nuria
dc.contributor.authorBenussi, Alberto
dc.contributor.authorCantoni, Valentina
dc.contributor.authorBertoux, Maxime
dc.contributor.authorBertrand, Anne
dc.contributor.authorBrice, Alexis
dc.contributor.authorLaforce, Robert
dc.contributor.authorCamuzat, Agnès
dc.contributor.authorColliot, Olivier
dc.contributor.authorSayah, Sabrina
dc.contributor.authorFunkiewiez, Aurélie
dc.contributor.authorRinaldi, Daisy
dc.contributor.authorLombardi, Gemma
dc.contributor.authorNacmias, Benedetta
dc.contributor.authorSaracino, Dario
dc.contributor.authorBessi, Valentina
dc.contributor.authorFerrari, Camilla
dc.contributor.authorGraff, Caroline
dc.contributor.authorCañada, Marta
dc.contributor.authorDeramecourt, Vincent
dc.contributor.authorKuchcinski, Gregory
dc.contributor.authorLebouvier, Thibaud
dc.contributor.authorOurselin, Sebastien
dc.contributor.authorPolito, Cristina
dc.contributor.authorRollin, Adeline
dc.contributor.authorSynofzik, Matthias
dc.contributor.authorGalimberti, Daniela
dc.contributor.authorRowe, James B.
dc.contributor.authorMasellis, Mario
dc.contributor.authorTartaglia, Carmela
dc.contributor.authorFinger, Elizabeth
dc.contributor.authorVandenberghe, Rik
dc.contributor.authorMedonça, Alexandre
dc.contributor.authorTagliavini, Fabrizio
dc.contributor.authorButler, Chris R.
dc.contributor.authorSantana, Isabel
dc.contributor.authorBer, Isabelle Le
dc.contributor.authorGerhard, Alex
dc.contributor.authorDucharme, Simon
dc.contributor.authorLevin, Johannes
dc.contributor.authorDanek, Adrian
dc.contributor.authorOtto, Markus
dc.contributor.authorSorbi, Sandro
dc.contributor.authorPasquier, Florence
dc.contributor.authorSwieten, John C.
dc.contributor.authorRohrer, Jonathan D.
dc.contributor.authorRossor, Martin N.
dc.contributor.authorFox, Nick C.
dc.contributor.authorWarren, Jason D.
dc.contributor.authorMoore, Katrina
dc.contributor.authorConvery, Rhian
dc.contributor.authorSwift, Imogen J.
dc.contributor.authorShafei, Rachelle
dc.contributor.authorHeller, Carolin
dc.contributor.authorTodd, Emily
dc.contributor.authorBouzigues, Arabella
dc.contributor.authorCash, David
dc.contributor.authorWoollacott, Ione
dc.contributor.authorZetterberg, Henrik
dc.contributor.authorNelson, Annabel
dc.contributor.authorNicholas, Jennifer
dc.contributor.authorGuerreiro, Rita
dc.contributor.authorBras, Jose
dc.contributor.authorThomas, David L.
dc.contributor.authorMead, Simon
dc.contributor.authorMeeter, Lieke
dc.contributor.authorPanman, Jessica
dc.contributor.authorMinkelen, Rick
dc.contributor.authorBarandiaran, Myriam
dc.contributor.authorIndakoetxea, Begoña
dc.contributor.authorGabilondo, Alazne
dc.contributor.authorTainta, Mikel
dc.contributor.authorGorostidi, Ana
dc.contributor.authorZulaica, Miren
dc.contributor.authorDíez, Alina
dc.contributor.authorVillanua, Jorge
dc.contributor.authorBorrego‐Ecija, Sergi
dc.contributor.authorJaume, Olives
dc.contributor.authorLladó, Albert
dc.contributor.authorBalasa, Mircea
dc.contributor.authorAntonell, Anna
dc.contributor.authorBargallo, Nuria
dc.contributor.authorPremi, Enrico
dc.contributor.authorGazzina, Stefano
dc.contributor.authorGasparotti, Roberto
dc.contributor.authorArchetti, Silvana
dc.contributor.authorBlack, Sandra
dc.contributor.authorMitchell, Sara
dc.contributor.authorRogaeva, Ekaterina
dc.contributor.authorFreedman, Morris
dc.contributor.authorKeren, Ron
dc.contributor.authorTang‐Wai, David
dc.contributor.authorThonberg, Hakan
dc.contributor.authorÖijerstedt, Linn
dc.contributor.authorAndersson, Christin
dc.contributor.authorJelic, Vesna
dc.contributor.authorArighi, Andrea
dc.contributor.authorFenoglio, Chiara
dc.contributor.authorScarpini, Elio
dc.contributor.authorFumagalli, Giorgio
dc.contributor.authorCope, Thomas
dc.contributor.authorTimberlake, Carolyn
dc.contributor.authorRittman, Timothy
dc.contributor.authorShoesmith, Christen
dc.contributor.authorBartha, Robart
dc.contributor.authorRademakers, Rosa
dc.contributor.authorWilke, Carlo
dc.contributor.authorKarnarth, Hans‐Otto
dc.contributor.authorBender, Benjamin
dc.date.accessioned2021-05-26T11:24:35Z
dc.date.available2021-05-26T11:24:35Z
dc.date.issued2021
dc.description© 2021 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.pt_PT
dc.description.abstractIntroduction: We aimed to assess episodic memory in genetic frontotemporal dementia (FTD) with the Free and Cued Selective Reminding Test (FCSRT). Methods: The FCSRT was administered in 417 presymptomatic and symptomatic mutation carriers (181 chromosome 9 open reading frame 72 [C9orf72], 163 progranulin [GRN], and 73 microtubule-associated protein tau [MAPT]) and 290 controls. Group differences and correlations with other neuropsychological tests were examined. We performed voxel-based morphometry to investigate the underlying neural substrates of the FCSRT. Results: All symptomatic mutation carrier groups and presymptomatic MAPT mutation carriers performed significantly worse on all FCSRT scores compared to controls. In the presymptomatic C9orf72 group, deficits were found on all scores except for the delayed total recall task, while no deficits were found in presymptomatic GRN mutation carriers. Performance on the FCSRT correlated with executive function, particularly in C9orf72 mutation carriers, but also with memory and naming tasks in the MAPT group. FCSRT performance also correlated with gray matter volumes of frontal, temporal, and subcortical regions in C9orf72 and GRN, but mainly temporal areas in MAPT mutation carriers. Discussion: The FCSRT detects presymptomatic deficits in C9orf72- and MAPT-associated FTD and provides important insight into the underlying cause of memory impairment in different forms of FTD.pt_PT
dc.description.sponsorshipThe Dementia Research Centre is supported by Alzheimer's Research UK, Alzheimer's Society, Brain Research UK, and The Wolfson Foundation. This work was supported by the NIHR UCL/H Biomedical Research Centre, the Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility, and the UK Dementia Research Institute, which receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society, and Alzheimer's Research UK. J. D. Rohrer is supported by an MRC Clinician Scientist Fellowship (MR/M008525/1) and has received funding from the NIHR Rare Disease Translational Research Collaboration (BRC149/NS/MH). This work was also supported by the MRC UK GENFI grant (MR/M023664/1); the Bluefield Project; the JPND GENFI-PROX grant (2019-02248); the Dioraphte Foundation (grant numbers 09-02-00); the Association for Frontotemporal Dementias Research Grant 2009; The Netherlands Organization for Scientific Research (NWO; grant HCMI 056-13-018); ZonMw Memorabel (Deltaplan Dementie, project numbers 733 050 103 and 733 050 813); JPND PreFrontAls consortium (project number 733051042). J. M. Poos is supported by a Fellowship award from Alzheimer Nederland (WE.15-2019.02). This work was conducted using the MRC Dementias Platform UK (MR/L023784/1 and MR/009076/1). Several authors of this publication are members of the European Reference Network for Rare Neurological Diseases - Project ID No 739510.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlzheimers Dement (Amst). 2021 May 13;13(1):e12185pt_PT
dc.identifier.doi10.1002/dad2.12185pt_PT
dc.identifier.eissn2352-8729
dc.identifier.urihttp://hdl.handle.net/10451/48179
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons, Inc.pt_PT
dc.relation.publisherversionhttps://alz-journals.onlinelibrary.wiley.com/journal/23528729pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCognitionpt_PT
dc.subjectEpisodic memorypt_PT
dc.subjectExecutive functionpt_PT
dc.subjectFrontal lobept_PT
dc.subjectFrontotemporal dementiapt_PT
dc.subjectGenetic disorderspt_PT
dc.subjectNeuropsychologypt_PT
dc.subjectTemporal lobept_PT
dc.subjectVoxel‐based morphometrypt_PT
dc.titleImpairment of episodic memory in genetic frontotemporal dementia : a GENFI studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.titleAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM)pt_PT
oaire.citation.volume13pt_PT
person.familyNameMiltenberger-Miltenyi
person.familyNameMaruta
person.familyNameVerdelho
person.familyNamePasquier
person.givenNameGabriel
person.givenNameCarolina
person.givenNameAna
person.givenNameFlorence
person.identifier173038
person.identifier.ciencia-idAE16-3A8D-0392
person.identifier.ciencia-id4B1D-5F59-6221
person.identifier.ciencia-idFC14-938F-EBBD
person.identifier.orcid0000-0003-0224-1281
person.identifier.orcid0000-0003-3359-379X
person.identifier.orcid0000-0003-4945-4946
person.identifier.orcid0000-0001-9880-9788
person.identifier.ridF-1527-2017
person.identifier.scopus-author-id35327513800
person.identifier.scopus-author-id6602902026
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication58c7f5b7-9f9d-42b6-9b39-c53dd40a79c7
relation.isAuthorOfPublication4a8bdaf9-480a-4836-ac4b-c80c3b4e0391
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relation.isAuthorOfPublication.latestForDiscovery318ba4cf-777f-4e71-befa-59a0651b3a76

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