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Association between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery disease

2021Artigo científico Acesso aberto
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dc.contributor.authorPereira-da-Silva, Tiago
dc.contributor.authorNapoleão, Patricia
dc.contributor.authorCosta, Marina C.
dc.contributor.authorGabriel, André F.
dc.contributor.authorSelas, Mafalda
dc.contributor.authorSilva, Filipa
dc.contributor.authorEnguita, Francisco J.
dc.contributor.authorCruz Ferreira, Rui
dc.contributor.authorCarmo, Miguel Mota
dc.date.accessioned2021-09-23T10:13:12Z
dc.date.available2021-09-23T10:13:12Z
dc.date.issued2021
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractBackground and Objectives: Tumor necrosis factor alpha (TNF-α) is proatherogenic and associated with the risk of acute ischemic events, although the mechanisms that regulate TNF-α expression in stable coronary artery disease (SCAD) are not fully understood. We investigated whether metabolic, inflammatory, and epigenetic (microRNA (miRNA)) markers are associated with TNF-α expression in SCAD. Materials and Methods: Patients with SCAD were prospectively recruited and their metabolic and inflammatory profiles were assessed. TNF-α levels were assessed using an enzyme-linked immunosorbent assay. The relative expression of six circulating miRNAs associated with the regulation of inflammation and/or atherosclerosis was determined. Results: Of the 24 included patients with the mean age of 65 (9) years, 88% were male, and 54% were diabetic. The TNF-α levels were (median (interquartile range)) 1.0 (0.7-1.1) pg/mL. The percentage of glycosylated hemoglobin (r = 0.418, p = 0.042), serum triglyceride levels (r = 0.429, p = 0.037), and C-reactive protein levels (r = 0.407, p = 0.048) were positively correlated with TNF-α levels. Of the candidate miRNAs, miR-146a expression levels were negatively correlated with TNF-α levels (as indicated by r = 0.500, p = 0.035 for correlation between delta cycle threshold (ΔCt) miR-146a and TNF-α levels). In multivariate analysis, serum triglyceride levels and miR-146a expression levels were independently associated with TNF-α levels. miR-146 expression levels were not associated with metabolic or other inflammatory parameters and were negatively correlated with the number of coronary vessels with obstructive disease (as indicated by r = 0.556, p = 0.017 for correlation between ΔCt miR-146a and number of diseased vessels). Conclusions: miR-146a expression levels were negatively correlated with TNF-α levels in patients with SCAD, irrespective of other metabolic or inflammatory markers, and with the severity of coronary artery disease. The results add to the knowledge on the role of miR-146a in TNF-α-based inflammation in SCAD and support future research on the potential therapeutic use of miR-146a in such a clinical scenario.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMedicina (Kaunas). 2021 Jun 4;57(6):575pt_PT
dc.identifier.doi10.3390/medicina57060575pt_PT
dc.identifier.eissn1648-9144
dc.identifier.urihttp://hdl.handle.net/10451/49586
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/medicinapt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectInflammationpt_PT
dc.subjectmiR-146apt_PT
dc.subjectmicroRNApt_PT
dc.subjectStable coronary artery diseasept_PT
dc.subjectTumor necrosis factor alphapt_PT
dc.titleAssociation between miR-146a and tumor necrosis factor alpha (TNF-α) in stable coronary artery diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue6pt_PT
oaire.citation.titleMedicinapt_PT
oaire.citation.volume57pt_PT
person.familyNamePereira-da-Silva
person.familyNameNapoleão
person.familyNameCosta
person.familyNameGabriel
person.familyNameEnguita
person.familyNameCarmo
person.givenNameTiago
person.givenNamePatrícia
person.givenNameMarina
person.givenNameAndré Filipe Gonçalves
person.givenNameFrancisco J.
person.givenNameMiguel
person.identifier887495
person.identifier173306
person.identifier.ciencia-idC11E-8BE9-A97F
person.identifier.ciencia-id6818-7810-6CEC
person.identifier.ciencia-id671C-AFF6-AF28
person.identifier.ciencia-idB215-8D49-3218
person.identifier.orcid0000-0003-0467-2608
person.identifier.orcid0000-0002-5896-1440
person.identifier.orcid0000-0001-9020-7539
person.identifier.orcid0000-0002-6565-1600
person.identifier.orcid0000-0002-8072-8557
person.identifier.orcid0000-0001-6865-4332
person.identifier.ridO-1710-2014
person.identifier.ridA-2347-2009
person.identifier.scopus-author-id8872775500
person.identifier.scopus-author-id55453276400
person.identifier.scopus-author-id57196534877
person.identifier.scopus-author-id6602119231
person.identifier.scopus-author-id7004005362
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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