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Publicação
Non‐classical major histocompatibility complex proteins as determinants of tumour immunosurveillance
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Orientador(es)
Resumo(s)
Tumours develop in vertebrate organisms endowed with immune systems that are potentially able to eradicate them. Nevertheless, our ever-increasing understanding of the complex interactions between lymphocytes and tumour cells fuels the long-standing hope of developing efficient immunotherapies against cancer. This review focuses on a versatile family of proteins, the major histocompatibility complex class Ib, which has been recently implicated in both the establishment of anti-tumour immune responses and in tumour immune response evasion. We focus on a subset of class Ib proteins, human leukocyte antigen (HLA)-G, Qa-2, CD1d and NKG2D ligands, which bind to either stimulatory or inhibitory receptors expressed on T, natural killer (NK) and NKT lymphocytes, and thereby modulate their anti-tumour activity.
Descrição
Copyright © 2007 European Molecular Biology Organization
Palavras-chave
MHC Cancer Innate Lymphocyte Natural killer
Contexto Educativo
Citação
EMBO Rep. 2007 Nov;8(11):1024-1030
Editora
EMBO Press