Publicação
Prognostic significance of disrhythmias in patients with familiar amyloid polyneuropathy
| dc.contributor.author | Francisco, A.R. Gaspar Lopes | |
| dc.contributor.author | Dias, N. Cortez | |
| dc.contributor.author | Menezes, M. N. | |
| dc.contributor.author | Guimarães, T. | |
| dc.contributor.author | Silva, G. Lima da | |
| dc.contributor.author | Plácido, R. | |
| dc.contributor.author | Magalhães, A. | |
| dc.contributor.author | Inácio, C. | |
| dc.contributor.author | Pinto, Fausto J. | |
| dc.contributor.author | Coutinho, C. Azevedo | |
| dc.date.accessioned | 2018-11-05T11:39:08Z | |
| dc.date.available | 2018-11-05T11:39:08Z | |
| dc.date.issued | 2016 | |
| dc.description | © 2016 European Society of Cardiology. All rights reserved. | pt_PT |
| dc.description.abstract | Background: Rhythm disturbances and conduction defects are common consequences of cardiac amyloid infiltration in familial amyloid polyneuropathy (FAP) V30M-TTR. The occurrence of dysrhythmias appears to increase with the severity of the disease but its prognostic value is still unknown. Purpose: To evaluate the occurrence of arrhythmias according to the patient's age and the duration of symptoms and to analyze its prognostic value. Methods: Prospective observational study of consecutive patients with FAP V30M-TTR who underwent annual cardiac evaluation including Holter recording. Results: During a median follow-up of 55 months, 223 patients were evaluated (44±14 years; 54.3% female) and a total of 777 Holter recordings were performed. It was found that with increasing age, the number of premature supraventricular (Pearson R=0.246, P<0.001, Spearman's Rho=0.246, P<0.001) and ventricular (Pearson R=0.244, P<0.001, Spearman's Rho=0.221, P<0.001) contractions increased, while the mean heart rate decreased (Pearson R=-0.448, P<0.001, Spearman Rho=-0.43, P<0.001). On the other hand, with increasing in symptoms duration, the number of premature ventricular contractions increased significantly (Pearson R=0.144, P=0.001, Spearman's Rho=0.165, P<0.001) (but not supraventricular) and the mean heart rate decreased (Pearson R=-0.153, P=0.001, Spearman's Rho=-0.185, P<0.001). Multivariate Cox regression analysis showed that the independent predictors of mortality were age (HR: 1.073, 95% CI 1.055–1.090), the presence of brady (HR: 1.615, 95% CI 1.071–2.436, P<0.001) or tachyarrhythmias (HR: 1.255, 95% CI 1.255–3.462, P<0.001) and the number of premature supraventricular contractions (HR: 1.439, 95% CI 1.168–1.774, P<0.001). Conclusions: Holter monitoring should be integrated in the periodic evaluation of FAP V30M-TTR patients. The presence of brady or tachyarrhythmias and the number of premature supraventricular contractions are associated with unfavorable prognosis in these patients and should be treated timely. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | European Heart Journal, Volume 37, Issue suppl_1, 1 August 2016, Pages 599–983 | pt_PT |
| dc.identifier.doi | 10.1093/eurheartj/ehw433 | pt_PT |
| dc.identifier.issn | 0195-668X | |
| dc.identifier.uri | http://hdl.handle.net/10451/35268 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.relation.publisherversion | https://academic.oup.com/eurheartj | pt_PT |
| dc.title | Prognostic significance of disrhythmias in patients with familiar amyloid polyneuropathy | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 684 | pt_PT |
| oaire.citation.startPage | 683 | pt_PT |
| oaire.citation.title | European Heart Journal | pt_PT |
| oaire.citation.volume | 37 | pt_PT |
| person.familyName | Pinto | |
| person.givenName | Fausto J. | |
| person.identifier | 1308889 | |
| person.identifier.ciencia-id | C311-AEDD-6DBB | |
| person.identifier.orcid | 0000-0002-8034-4529 | |
| person.identifier.rid | G-9363-2015 | |
| person.identifier.scopus-author-id | 7102740158 | |
| rcaap.rights | restrictedAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isAuthorOfPublication | 5f44176f-69f5-482c-83cd-ab94425a6ec3 | |
| relation.isAuthorOfPublication.latestForDiscovery | 5f44176f-69f5-482c-83cd-ab94425a6ec3 |