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Neuromuscular transmission modulation by adenosine upon aging

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dc.contributor.authorPousinha, Paula A.
dc.contributor.authorCorreia, Alexandra M.
dc.contributor.authorSebastião, Ana M
dc.contributor.authorRibeiro, Joaquim A.
dc.date.accessioned2012-10-15T11:32:33Z
dc.date.available2012-10-15T11:32:33Z
dc.date.issued2012
dc.description© 2012 Elsevier Inc. All rights reserved.por
dc.description.abstractIn infant rats adenosine A2A receptor-mediated modulation of neuromuscular transmission predominates over A1 receptor-mediated neuromodulation.We investigated whether aging affects this A2A/A1 receptor balance. Evoked (EPPs) and miniature end plate potentials(MEPPs) were recorded from single fibers of (weeks-old) infant (3– 4), young adult (12–16), older (36 –38),and aged (80 –90) male rat-diaphragm. The non A1/A2A selective agonist, 2-chloroadenosine (CADO; 30 nM) and the adenosine kinase inhibitor, iodotubericidin (ITU; 10 M) increased mean amplitude and quantal content of EPPs in infant, young adult, and older adult rats, but not in aged rats. The facilitatory effects were prevented by the A2A receptor antagonist,ZM241385 (50 nM) and mimicked by the A2A receptor agonist,CGS21680 (10 nM). The A1 receptor agonist, 6-cyclopentyladenosine (CPA; 100 nM), decreased EPPs amplitude in all age groups. It is concluded that aging differently influences adenosine A1 receptor and A2A receptor-mediated presynaptic modulation of neuromuscular transmission, so that the facilitatory influence decreases upon aging, whereas the inhibitory influence remains unchanged in aged animals. The reduction of adenosine A2A receptors upon aging may contribute to the age-related changes in neuromuscular function.eng
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal and European Union (Grant NEREPLAS, COST B30).eng
dc.identifier.citationNeurobiology of Aging 33 (2012) 2869–2880por
dc.identifier.issn0197-4580
dc.identifier.urihhtp://dx.doi.org/10.1016/j.neurobiolaging.2012.01.008
dc.identifier.urihttp://hdl.handle.net/10451/7048
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relationFAST AND SLOW ACTIONS OF ADENOSINE AND BDNF ON MOTOR NEURONS
dc.subjectAgingeng
dc.subjectAdenosine receptorseng
dc.subjectNeuromuscular transmissioneng
dc.subjectNeuromuscular junctioneng
dc.subjectEPPseng
dc.subjectMEPPseng
dc.titleNeuromuscular transmission modulation by adenosine upon agingpor
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/28073/2006
oaire.awardTitleFAST AND SLOW ACTIONS OF ADENOSINE AND BDNF ON MOTOR NEURONS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/PIDDAC/SFRH%2FBD%2F28073%2F2006/PT
oaire.citation.endPage2880por
oaire.citation.startPage2869por
oaire.citation.titleNeurobiology of Agingpor
oaire.fundingStreamPIDDAC
person.familyNameSebastião
person.familyNameRibeiro
person.givenNameAna M
person.givenNameJoaquim
person.identifier.ciencia-idF112-55E8-E37E
person.identifier.ciencia-id081F-2518-907F
person.identifier.orcid0000-0001-9030-6115
person.identifier.orcid0000-0002-9330-3507
person.identifier.scopus-author-id7004409879
person.identifier.scopus-author-id35498669400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication304abd7f-071b-4447-a8a3-4aa5f0547141
relation.isAuthorOfPublication86da944c-5e6a-4ec5-a56e-4ed82ece7a17
relation.isAuthorOfPublication.latestForDiscovery304abd7f-071b-4447-a8a3-4aa5f0547141
relation.isProjectOfPublication254dd1f6-5ae6-4700-aee9-baf7b48872b0
relation.isProjectOfPublication.latestForDiscovery254dd1f6-5ae6-4700-aee9-baf7b48872b0

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