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Canine parvovirus : a predicting canine model for sepsis

2020-06-15Artigo científico Acesso aberto
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dc.contributor.authorAlves, F.
dc.contributor.authorPrata, S.
dc.contributor.authorNunes, Telmo
dc.contributor.authorGomes, J.
dc.contributor.authorAguiar, Sandra
dc.contributor.authorAires da Silva, Frederico
dc.contributor.authorTavares, Luis
dc.contributor.authorAlmeida, Virgilio
dc.contributor.authorGil, Solange
dc.date.accessioned2022-04-11T15:53:46Z
dc.date.available2022-04-11T15:53:46Z
dc.date.issued2020-06-15
dc.descriptionResearch Areas: Veterinary Sciencespt_PT
dc.description.abstractBackground: Sepsis is a severe condition associated with high prevalence and mortality rates. Parvovirus enteritis is a predisposing factor for sepsis, as it promotes intestinal bacterial translocation and severe immunosuppression. This makes dogs infected by parvovirus a suitable study population as far as sepsis is concerned. The main objective of the present study was to evaluate the differences between two sets of SIRS (Systemic Inflammatory Response Syndrome) criteria in outcome prediction: SIRS 1991 and SIRS 2001. The possibility of stratifying and classifying septic dogs was assessed using a proposed animal adapted PIRO (Predisposition, Infection, Response and Organ dysfunction) scoring system. Results: The 72 dogs enrolled in this study were scored for each of the PIRO elements, except for Infection, as all were considered to have the same infection score, and subjected to two sets of SIRS criteria, in order to measure their correlation with the outcome. Concerning SIRS criteria, it was found that the proposed alterations on SIRS 2001 (capillary refill time or mucous membrane colour alteration) were significantly associated with the outcome (OR = 4.09, p < 0.05), contrasting with the 1991 SIRS criteria (p = 0.352) that did not correlate with the outcome. No significant statistical association was found between Predisposition (p = 1), Response (p = 0.1135), Organ dysfunction (p = 0.1135), total PIRO score (p = 0.093) and outcome. To explore the possibility of using the SIRS criteria as a fast decision-making tool, a Fast-andFrugal tree (FFT) was created with a sensitivity of 92% and a specificity of 29%. Conclusion: These results suggest that increasing the SIRS criteria specificity may improve their prognostic value and their clinical usefulness. In order to improve the proposed PIRO scoring system outcome prediction ability, more specific criteria should be added, mainly inflammatory and organ dysfunction biomarkers.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves F, Prata S, Nunes T, Gomes J, Aguiar S, Aires da Silva F, Tavares L, Almeida V, Gil S. 2020. Canine parvovirus : a predicting canine model for sepsis. BMC Veterinary Research, 16(1):199. Doi 10.1186/s12917-020-02417-0pt_PT
dc.identifier.doi10.1186/s12917-020-02417-0pt_PT
dc.identifier.eissn1746-6148
dc.identifier.urihttp://hdl.handle.net/10400.5/24068
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relationUIDP/CVT/00276/2020pt_PT
dc.relationDL57/2016/CP1438/CT0002pt_PT
dc.relation.publisherversionhttps://bmcvetres.biomedcentral.com/track/pdf/10.1186/s12917-020-02417-0.pdfpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCanine parvoviruspt_PT
dc.subjectSepsispt_PT
dc.subjectSIRSpt_PT
dc.subjectPIROpt_PT
dc.titleCanine parvovirus : a predicting canine model for sepsispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceEnglandpt_PT
oaire.citation.titleBMC Veterinary Researchpt_PT
oaire.citation.volume16(1)pt_PT
person.familyNameLandeiro Raposo Pina Nunes
person.familyNameAires da Silva
person.familyNameMorgado Tavares
person.familyNameAlmeida
person.familyNameGil Neves
person.givenNameTelmo Renato
person.givenNameFrederico
person.givenNameLuis Manuel
person.givenNameVirgilio
person.givenNameSolange
person.identifier143307
person.identifier.ciencia-id2C1A-E281-3E6F
person.identifier.ciencia-id4410-6DA0-C74C
person.identifier.ciencia-id9011-18C6-482D
person.identifier.ciencia-id4212-3A73-3484
person.identifier.ciencia-id2E16-4021-64AB
person.identifier.orcid0000-0003-4388-5366
person.identifier.orcid0000-0002-3821-419X
person.identifier.orcid0000-0001-8671-6285
person.identifier.orcid0000-0001-9565-6261
person.identifier.scopus-author-id8519566800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationacbacc01-80c6-4ac1-9eab-ce8daa65442c
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