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The perfect condition for the rising of superbugs: person-to-person contagion and antibiotic use are the key factors responsible for the positive correlation between antibiotic resistance gene diversity and virulence gene diversity in human metagenomes

2020-04-26Journal article Open access
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dc.contributor.authorDomingues, Célia P. F.
dc.contributor.authorRebelo, João S.
dc.contributor.authorNogueira, Teresa
dc.contributor.authorPothier, Joel
dc.contributor.authorMonteiro, Francisca
dc.contributor.authorDionisio, Francisco
dc.date.accessioned2021-04-22T18:45:27Z
dc.date.available2021-04-22T18:45:27Z
dc.date.issued2020-04-26
dc.description.abstractThis study aims to understand the cause of the recent observation that humans with a higher diversity of virulence genes in their metagenomes tend to be precisely those with higher diversity of antibiotic-resistance genes. We simulated the transferring of virulence and antibiotic-resistance genes in a community of interacting people where some take antibiotics. The diversities of the two genes types became positively correlated whenever the contagion probability between two people was higher than the probability of losing resistant genes. However, no such positive correlations arise if no one takes antibiotics. This finding holds even under changes of several simulations’ parameters, such as the relative or total diversity of virulence and resistance genes, the contagion probability between individuals, the loss rate of resistance genes, or the social network type. Because the loss rate of resistance genes may be shallow, we conclude that the contagion between people and antibiotic usage is the leading cause of establishing the positive correlation mentioned above. Therefore, antibiotic use and something as prosaic as the contagion between people may facilitate the emergence of virulent and multi-resistant bacteria in people’s metagenomes with a high diversity of both gene types. These superbugs may then circulate in the community.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1101/2020.04.25.061853pt_PT
dc.identifier.urihttp://hdl.handle.net/10451/47526
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.publisherBioRxivpt_PT
dc.relationALG-01-0145-FEDER-028824pt_PT
dc.relationFCT SFRH/BPD/123504/2016pt_PT
dc.relationFCt UIDP/00329/2020 (cE3c)pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/pt_PT
dc.subjectcomputer simulations; antibiotic resistance; microbiomept_PT
dc.titleThe perfect condition for the rising of superbugs: person-to-person contagion and antibiotic use are the key factors responsible for the positive correlation between antibiotic resistance gene diversity and virulence gene diversity in human metagenomespt_PT
dc.typejournal article
dspace.entity.typePublication
person.familyNameDomingues
person.familyNameRebelo
person.familyNameVitorino Nogueira
person.familyNamePothier
person.familyNameSarreira Simões Horta Monteiro
person.familyNameDionísio
person.givenNameCélia
person.givenNameJoão
person.givenNameTeresa Isabel
person.givenNameJoel
person.givenNameFrancisca
person.givenNameFrancisco
person.identifierG-2273-2010
person.identifierA-2129-2009
person.identifier.ciencia-id3416-6299-1379
person.identifier.ciencia-idA015-FF75-397C
person.identifier.ciencia-idF211-4E18-2C69
person.identifier.ciencia-idA815-CE3A-53C9
person.identifier.ciencia-id7413-DB46-16E0
person.identifier.orcid0000-0003-2970-010X
person.identifier.orcid0000-0002-8662-7378
person.identifier.orcid0000-0002-0059-5177
person.identifier.orcid0000-0002-4021-6055
person.identifier.orcid0000-0002-5275-714X
person.identifier.orcid0000-0002-3653-1511
person.identifier.scopus-author-id7004351448
person.identifier.scopus-author-id6506790127
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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