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CD44v6 high membranous expression is a predictive marker of therapy response in gastric cancer patients

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dc.contributor.authorAlmeida, Gabriela M
dc.contributor.authorPereira, Carla
dc.contributor.authorPark, Ji-Hyeon
dc.contributor.authorLemos, Carolina
dc.contributor.authorCampelos, Sofia
dc.contributor.authorGullo, Irene
dc.contributor.authorMartins, Diana
dc.contributor.authorGonçalves, Gilza
dc.contributor.authorLeitão, Dina
dc.contributor.authorNeto, João Luís
dc.contributor.authorAndré, Ana
dc.contributor.authorBorges, Clara
dc.contributor.authorAlmeida, Daniela
dc.contributor.authorLee, Hyuk-Joon
dc.contributor.authorKong, Seong-Ho
dc.contributor.authorKim, Woo Ho
dc.contributor.authorCarneiro, Fátima
dc.contributor.authorAlmeida, Raquel
dc.contributor.authorYang, Han-Kwang
dc.contributor.authorOliveira, Carla
dc.date.accessioned2021-09-28T14:45:28Z
dc.date.available2021-09-28T14:45:28Z
dc.date.issued2021
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractIn gastric cancer (GC), biomarkers that define prognosis and predict treatment response remain scarce. We hypothesized that the extent of CD44v6 membranous tumor expression could predict prognosis and therapy response in GC patients. Two GC surgical cohorts, from Portugal and South Korea (n = 964), were characterized for the extension of CD44v6 membranous immuno-expression, clinicopathological features, patient survival, and therapy response. The value of CD44v6 expression in predicting response to treatment and its impact on prognosis was determined. High CD44v6 expression was associated with invasive features (perineural invasion and depth of invasion) in both cohorts and with worse survival in the Portuguese GC cohort (HR 1.461; 95% confidence interval 1.002-2.131). Patients with high CD44v6 tumor expression benefited from conventional chemotherapy in addition to surgery (p < 0.05), particularly those with heterogeneous CD44v6-positive and -negative populations (CD44v6_3+) (p < 0.007 and p < 0.009). Our study is the first to identify CD44v6 high membranous expression as a potential predictive marker of response to conventional treatment, but it does not clarify CD44v6 prognostic value in GC. Importantly, our data support selection of GC patients with high CD44v6-expressing tumors for conventional chemotherapy in addition to surgery. These findings will allow better stratification of GC patients for treatment, potentially improving their overall survival.pt_PT
dc.description.sponsorshipThis work was funded by FEDER-Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020–Operacional Programme for Competitiveness and Internationalization (POCI), Portugal 2020, and by Portuguese funds through FCT–Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Inovação in the framework of the project “Institute for Research and Innovation in Health Sciences” (POCI-01-0145-FEDER-007274). This work was also financed by the projects NORTE-01-0145-FEDER-000003 and NORTE-01-0145-FEDER-000029, supported by the Norte Portugal Regional Programme (NORTE 2020) under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF); project POCI-01-0145-FEDER-016390 and SAICTPAC/0022/2015, funded by ERDF, POCI, and FCT; project PTDC/CTM-NAN/120958/2010, from FCT; and by project PTDC/BTM-TEC/30164/2017 funded by ERDF funds through the COMPETE 2020–POCI, Portugal 2020, and by FCT. Salary support to G.M.A. by PTDC/BTM-TEC/30164/2017 project; C.P. was supported by the grant SFRH/BD/113031/2015 from FCT.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBiomedicines. 2021 Sep 18;9(9):1249pt_PT
dc.identifier.doi10.3390/biomedicines9091249pt_PT
dc.identifier.eissn2227-9059
dc.identifier.urihttp://hdl.handle.net/10451/49663
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationPOCI-01-0145-FEDER-007274pt_PT
dc.relationNORTE-01-0145-FEDER-000003pt_PT
dc.relationNORTE-01-0145-FEDER-000029pt_PT
dc.relationPOCI-01-0145-FEDER-016390pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/journal/biomedicinespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBiomarkerspt_PT
dc.subjectConventional chemotherapypt_PT
dc.subjectDrug therapypt_PT
dc.subjectGastric surgerypt_PT
dc.subjectGenetic heterogeneitypt_PT
dc.subjectStomach neoplasmspt_PT
dc.titleCD44v6 high membranous expression is a predictive marker of therapy response in gastric cancer patientspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumber148074
oaire.awardNumberPTDC/CTM-NAN/120958/2010
oaire.awardNumber151351
oaire.awardNumber48611
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/148074/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/PTDC%2FCTM-NAN%2F120958%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/151351/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/48611/PT
oaire.citation.issue9pt_PT
oaire.citation.titleBiomedicinespt_PT
oaire.citation.volume9pt_PT
oaire.fundingStream9471 - RIDTI
oaire.fundingStream5876-PPCDTI
oaire.fundingStream9471 - RIDTI
oaire.fundingStreamPOR_NORTE
person.familyNameAguiar Martins Neto
person.givenNameJoão Luís
person.identifier.ciencia-idE512-57B7-6129
person.identifier.orcid0000-0003-0863-158X
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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