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Evolution of resistance and disease tolerance mechanisms to oral bacterial infection in Drosophila melanogaster

2025-03Artigo científico Acesso aberto
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dc.contributor.authorPaulo, Tânia F.
dc.contributor.authorAkyaw, Priscilla A.
dc.contributor.authorPaixão, Tiago
dc.contributor.authorSucena, Élio
dc.date.accessioned2025-04-14T12:42:14Z
dc.date.available2025-04-14T12:42:14Z
dc.date.issued2025-03
dc.description.abstractPathogens exert strong selection on hosts that evolve and deploy different defensive strategies, namely minimizing pathogen exposure (avoidance), directly promoting pathogen elimination (resistance) and/or managing the deleterious effects of illness (disease tolerance). However, how the host response partitions across these processes has not been directly tested in a single host–pathogen system, let alone in the context of known adaptive trajectories resulting from experimental evolution. Here, we compare a Drosophila melanogaster population adapted to oral infection with its natural pathogen Pseudomonas entomophila (BactOral), to its control population to find no evidence for behavioural changes but measurable differences in both resistance and disease tolerance. In BactOral, no differences were detected in bacterial intake or defecation, nor gut cell renewal. However, a measurable relative decrease in bacterial loads correlates with an increase in gut-specific anti-microbial peptide production, pointing to a strengthening in resistance. Additionally, we posit that disease tolerance also contributes to the response of BactOral through a tighter control of self- and pathogen-derived damage caused by bacteria exposure. This study reveals a genetically complex and mechanistically multi-layered response, possibly reflecting the structure of adaptation to infection in natural populations.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPaulo Tânia F., Akyaw Priscilla A., Paixão Tiago and Sucena Élio 2025Evolution of resistance and disease tolerance mechanisms to oral bacterial infection in Drosophila melanogasterOpen Biol.15240265 http://doi.org/10.1098/rsob.240265pt_PT
dc.identifier.doi10.1098/rsob.240265pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/100193
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Royal Societypt_PT
dc.relationInstituto Gulbenkian de Ciência/Fundação Calouste Gulbenkian and FCT-Fundação para a Ciência e a Tecnologia (Portugal), through UID/Multi/04555/2013 and UIDB/00329/2020.pt_PT
dc.relationFCT—Fundação para a Ciência e a Tecnologia (Portugal) funded the PhD fellowships of T.F.P. (BD/128432/2017 and COVID/BD/151645/2021) and of P.A.A. (BD/06404/2020), and the project PTDC/BIA-BIO/4693/2021.pt_PT
dc.relationC.S. CONGENTO, project LISBOA-01-0145-FEDER-022170, co-financed by Lisboa Regional Operational Programme (Lisboa 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and Foundation for Science and Technology (Portugal)pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleEvolution of resistance and disease tolerance mechanisms to oral bacterial infection in Drosophila melanogasterpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.titleOpen Biologypt_PT
oaire.citation.volume15pt_PT
person.familyNameda Silva Sucena
person.givenNameJosé Élio
person.identifierhttps://scholar.google.com/citations?user=G8IMng8AAAAJ&hl=en
person.identifier.ciencia-id801C-77F5-F8B7
person.identifier.orcid0000-0001-8810-870X
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3b75db45-f117-4d08-9bd3-1dc430e252ec
relation.isAuthorOfPublication.latestForDiscovery3b75db45-f117-4d08-9bd3-1dc430e252ec

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