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Chemical, Cytotoxic, and Anti-Inflammatory Assessment of Honey Bee Venom from Apis mellifera intermissa

2021Journal article Open access
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dc.contributor.authorEl Mehdi, Iouraouine
dc.contributor.authorFalcão, Soraia I.
dc.contributor.authorHarandou, Mustapha
dc.contributor.authorBoujraf, Said
dc.contributor.authorCalhelha, Ricardo C.
dc.contributor.authorFerreira, Isabel C.F.R.
dc.contributor.authorAnjos, Ofélia
dc.contributor.authorCampos, Maria G.
dc.contributor.authorVilas-Boas, Miguel
dc.date.accessioned2022-01-25T10:58:15Z
dc.date.available2022-01-25T10:58:15Z
dc.date.issued2021
dc.description.abstractThe venom from Apis mellifera intermissa, the main honey bee prevailing in Morocco, has been scarcely studied, despite its known potential for pharmacological applications. In the present work, we investigated the composition, the anti-inflammatory activity, and the venom’s cytotoxic properties from fifteen honey bee venom (HBV) samples collected in three regions: northeast, central, and southern Morocco. The chemical assessment of honey bee venom was performed using LC-DAD/ESI/MSn, NIR spectroscopy and AAS spectroscopy. The antiproliferative effect was evaluated using human tumor cell lines, including breast adenocarcinoma, non-small cell lung carcinoma, cervical carcinoma, hepatocellular carcinoma, and malignant melanoma. Likewise, we assessed the anti-inflammatory activity using the murine macrophage cell line. The study provides information on the honey bee venom subspecies’ main components, such as melittin, apamin, and phospholipase A2, with compositional variation depending on the region of collection. Contents of toxic elements such as cadmium, chromium, and plumb were detected at a concentration below 5 ppm, which can be regarded as safe for pharmaceutical use. The data presented contribute to the first study in HBV from Apis mellifera intermissa and highlight the remarkable antiproliferative and anti-inflammatory effects of HBV, suggesting it to be a candidate natural medicine to explorept_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEl Mehdi, I.; Falcão, S.I.; Harandou, M.; Boujraf, S.; Calhelha, R.C.; Ferreira, I.C.F.R.; Anjos, O.; Campos, M.G.; Vilas-Boas, M. Chemical, Cytotoxic, and Anti-Inflammatory Assessment of Honey Bee Venom from Apis mellifera intermissa. Antibiotics 2021, 10, 1514pt_PT
dc.identifier.doihttps://doi.org/10.3390/ antibiotics10121514pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/23251
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMountain Research Center
dc.relationForest Research Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectbee venompt_PT
dc.subjectApis mellifera intermissapt_PT
dc.subjectanti-inflammatory activitypt_PT
dc.subjectcytotoxic activitypt_PT
dc.subjectchemical compositionpt_PT
dc.subjectNIRpt_PT
dc.titleChemical, Cytotoxic, and Anti-Inflammatory Assessment of Honey Bee Venom from Apis mellifera intermissapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleForest Research Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00239%2F2020/PT
oaire.citation.titleAntibioticspt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationa0fd44f4-e208-4e8c-8e28-483928b179fc
relation.isProjectOfPublication56bd0ae9-f8da-4344-b9a2-f633d4f68b89
relation.isProjectOfPublication.latestForDiscovery56bd0ae9-f8da-4344-b9a2-f633d4f68b89

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