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Etiology and risk factors for Rheumatoid Arthritis: a state-of-the-art review

2021Journal article Open access
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dc.contributor.authorRomão, Vasco C.
dc.contributor.authorFonseca, João Eurico
dc.date.accessioned2021-12-14T15:54:33Z
dc.date.available2021-12-14T15:54:33Z
dc.date.issued2021
dc.descriptionCopyright © 2021 Romão and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractRheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It is associated with significant burden at the patient and societal level. Extensive efforts have been devoted to identifying a potential cause for the development of RA. Epidemiological studies have thoroughly investigated the association of several factors with the risk and course of RA. Although a precise etiology remains elusive, the current understanding is that RA is a multifactorial disease, wherein complex interactions between host and environmental factors determine the overall risk of disease susceptibility, persistence and severity. Risk factors related to the host that have been associated with RA development may be divided into genetic; epigenetic; hormonal, reproductive and neuroendocrine; and comorbid host factors. In turn, environmental risk factors include smoking and other airborne exposures; microbiota and infectious agents; diet; and socioeconomic factors. In the present narrative review, aimed at clinicians and researchers in the field of RA, we provide a state-of-the-art overview of the current knowledge on this topic, focusing on recent progresses that have improved our comprehension of disease risk and development.pt_PT
dc.description.sponsorshipVCR work was funded by Fundação para a Ciência e Tecnologia (Interno Doutorando Bursary reference SFRH/SINTD/95030/2013); European League Against Rheumatism (EULAR Scientific Training Bursary 2014); and Sociedade Portuguesa de Reumatologia (Fundo de Apoio à Investigação da SPR 2015 & 2016, to VCR).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Med (Lausanne). 2021 Nov 26;8:689698pt_PT
dc.identifier.doi10.3389/fmed.2021.689698pt_PT
dc.identifier.eissn2296-858X
dc.identifier.urihttp://hdl.handle.net/10451/50413
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationSYNOVIAL PATHOBIOLOGY AND PATIENT STRATIFICATION IN RHEUMATOID ARTHRITIS
dc.relation.publisherversionhttps://www.frontiersin.org/journals/medicine#pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectEtiologypt_PT
dc.subjectPathogenesispt_PT
dc.subjectPre-RApt_PT
dc.subjectPre-rheumatoid arthritispt_PT
dc.subjectRheumatoid arthritispt_PT
dc.subjectRisk factorspt_PT
dc.titleEtiology and risk factors for Rheumatoid Arthritis: a state-of-the-art reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleSYNOVIAL PATHOBIOLOGY AND PATIENT STRATIFICATION IN RHEUMATOID ARTHRITIS
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FSINTD%2F95030%2F2013/PT
oaire.citation.titleFrontiers in Medicinept_PT
person.familyNameC Romão
person.familyNameFonseca
person.givenNameVasco
person.givenNameJoão
person.identifier490119
person.identifier.ciencia-id771D-0A5C-626B
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.orcid0000-0002-5603-9436
person.identifier.orcid0000-0003-1432-3671
person.identifier.ridO-8224-2014
person.identifier.scopus-author-id55989452300
person.identifier.scopus-author-id7101983519
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication1772dc12-7c55-4c76-ae2d-c23270172480
relation.isAuthorOfPublication.latestForDiscovery1772dc12-7c55-4c76-ae2d-c23270172480
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