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Purine nucleosides in neuroregeneration and neuroprotection

2016Journal article Restricted access
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dc.contributor.authorRibeiro, Filipa
dc.contributor.authorXapelli, Sara
dc.contributor.authorMiranda-Lourenço, Catarina
dc.contributor.authorTanqueiro, Sara
dc.contributor.authorFonseca-Gomes, João
dc.contributor.authorDiógenes, Maria José
dc.contributor.authorRibeiro, Joaquim A.
dc.contributor.authorSebastião, Ana M
dc.date.accessioned2021-09-21T15:53:14Z
dc.date.available2021-09-21T15:53:14Z
dc.date.issued2016
dc.description© 2015 Elsevier Ltd. All rights reserved.pt_PT
dc.description.abstractIn the present review, we stress the importance of the purine nucleosides, adenosine and guanosine, in protecting the nervous system, both centrally and peripherally, via activation of their receptors and intracellular signalling mechanisms. A most novel part of the review focus on the mechanisms of neuronal regeneration that are targeted by nucleosides, including a recently identified action of adenosine on axonal growth and microtubule dynamics. Discussion on the role of the purine nucleosides transversally with the most established neurotrophic factors, e.g. brain derived neurotrophic factor (BDNF), glial derived neurotrophic factor (GDNF), is also focused considering the intimate relationship between some adenosine receptors, as is the case of the A2A receptors, and receptors for neurotrophins. This article is part of the Special Issue entitled 'Purines in Neurodegeneration and Neuroregeneration'.pt_PT
dc.description.sponsorshipThe authors work has been funded by Fundação para a Ciência e Tecnologia (FCT) Portugal (EXPL/BIM-MEC/0009/2013). Filipa F Ribeiro was in receipt of a fellowship (SFRH/BD/74662/2010) from FCTpt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNeuropharmacology. 2016 May;104:226-242pt_PT
dc.identifier.doi10.1016/j.neuropharm.2015.11.006pt_PT
dc.identifier.eissn1873-7064
dc.identifier.issn0028-3908
dc.identifier.urihttp://hdl.handle.net/10451/49567
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationAdenosine receptors: new pharmacological targets for Rett syndrome treatment
dc.relationADENOSINE A2A RECEPTOR MODULATION OF NEURONAL MATURATION
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/neuropharmacologypt_PT
dc.subjectAdenosinept_PT
dc.subjectAxon growthpt_PT
dc.subjectGuanosinept_PT
dc.subjectNeuroprotectionpt_PT
dc.subjectNeurotrophic factorspt_PT
dc.subjectRegenerationpt_PT
dc.titlePurine nucleosides in neuroregeneration and neuroprotectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleAdenosine receptors: new pharmacological targets for Rett syndrome treatment
oaire.awardTitleADENOSINE A2A RECEPTOR MODULATION OF NEURONAL MATURATION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FBIM-MEC%2F0009%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F74662%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/31396/PT
oaire.citation.endPage242pt_PT
oaire.citation.startPage226pt_PT
oaire.citation.titleNeuropharmacologypt_PT
oaire.citation.volume104pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamOE
person.familyNameRibeiro
person.familyNameXapelli
person.familyNameMiranda Lourenço
person.familyNameTanqueiro
person.familyNameFonseca-Gomes
person.familyNamede Oliveira Diógenes Nogueira
person.familyNameRibeiro
person.familyNameSebastião
person.givenNameFilipa
person.givenNameSara
person.givenNameCatarina
person.givenNameSara
person.givenNameJoão
person.givenNameMaria José
person.givenNameJoaquim
person.givenNameAna M
person.identifier129383
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person.identifier.ciencia-id081F-2518-907F
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person.identifier.orcid0000-0002-4006-7328
person.identifier.orcid0000-0001-6854-2509
person.identifier.orcid0000-0002-9633-7999
person.identifier.orcid0000-0002-9151-7149
person.identifier.orcid0000-0001-7915-3517
person.identifier.orcid0000-0001-5486-6246
person.identifier.orcid0000-0002-9330-3507
person.identifier.orcid0000-0001-9030-6115
person.identifier.ridS-1079-2018
person.identifier.scopus-author-id8721560200
person.identifier.scopus-author-id35498669400
person.identifier.scopus-author-id7004409879
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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