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Major determinants of primary non function from kidney donation after Maastricht II circulatory death: a single center experience

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dc.contributor.authorGaspar, Ana
dc.contributor.authorGama, Madalena
dc.contributor.authorNobre De Jesus, Gustavo
dc.contributor.authorQuerido, Sara
dc.contributor.authorDamas, Juliana
dc.contributor.authorOliveira, João
dc.contributor.authorNeves, Marta
dc.contributor.authorSantana, Alice
dc.contributor.authorRibeiro, João Miguel
dc.date.accessioned2024-07-24T14:16:44Z
dc.date.available2024-07-24T14:16:44Z
dc.date.issued2024
dc.description© 2024 Elsevier Inc. All rights reserved.pt_PT
dc.description.abstractPurpose: Organ shortage greatly limits treatment of patients with end-stage chronic kidney. Maastricht type 2 donation after circulatory death (DCD) has been shown to have similar results in long term outcomes in kidney transplantation, when compared with brain dead donation. Our main goal was to assess Maastricht type 2 DCD and evaluate factors that impact on early graft function. Methods: A retrospective study was conducted in an ECMO Referral Centre. All patients who received a kidney transplant from Maastricht type 2 DCD were included in study. Early graft function and short term outcomes were assessed. Results: From October 2017 to December 2022, 47 renal grafts were collected from 24 uDCD donors. Median warm ischemia time was 106 min (94-115), cannulation time was 10 min (8; 20) and duration of extracorporeal reperfusion (ANOR) was 180 min (126-214). Regarding early graft function, 25% had immediate graft function, 63.6% had delayed graft function and 11.4% had primary non-function (PNF). There was a correlation between cannulation time (p = 0.006) and ANOR with PNF (p = 0.016). Conclusions: Cannulation time and ANOR were the main factors that correlated with PNF. Better understanding of underlying mechanisms should be sought in future studies to reduce the incidence of PNF.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Crit Care. 2024 Aug:82:154811pt_PT
dc.identifier.doi10.1016/j.jcrc.2024.154811pt_PT
dc.identifier.eissn1557-8615
dc.identifier.issn0883-9441
dc.identifier.urihttp://hdl.handle.net/10451/65458
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/journal-of-critical-carept_PT
dc.subjectAbdominal organ normothermic reperfusionpt_PT
dc.subjectCannulation timept_PT
dc.subjectKidney transplantationpt_PT
dc.subjectMaastricht type 2 donation after circulatory deathpt_PT
dc.subjectPrimary graft non functionpt_PT
dc.titleMajor determinants of primary non function from kidney donation after Maastricht II circulatory death: a single center experiencept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Critical Carept_PT
oaire.citation.volume82pt_PT
person.familyNameNobre de Jesus
person.familyNameQuerido Conde
person.familyNameDamas
person.familyNameMarques Fernandes de Oliveira
person.givenNameGustavo
person.givenNameSara
person.givenNameJuliana
person.givenNameJoão
person.identifier.ciencia-id0116-3863-5ECD
person.identifier.ciencia-id3510-CBA7-3878
person.identifier.orcid0000-0003-1042-3392
person.identifier.orcid0000-0003-2325-1817
person.identifier.orcid0000-0002-1684-6794
person.identifier.orcid0000-0001-5097-9630
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationac125b6b-e437-4b08-a60c-20debf8722bf
relation.isAuthorOfPublicationa0a73af0-e3d4-4fd8-ba73-443c3f33ae57
relation.isAuthorOfPublicationf742d0f2-7b94-45e3-91fb-c29829727690
relation.isAuthorOfPublication361f06e8-cc4d-4f53-ba05-e50221b1b9b7
relation.isAuthorOfPublication.latestForDiscoveryf742d0f2-7b94-45e3-91fb-c29829727690

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