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Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study

2022-04-11Journal article Open access
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dc.contributor.authorMonteiro, Marta
dc.contributor.authorPrata, Sara
dc.contributor.authorCardoso, Luís
dc.contributor.authorPereira da Fonseca, Isabel
dc.contributor.authorLeal, Rodolfo
dc.date.accessioned2023-02-22T11:29:35Z
dc.date.available2023-02-22T11:29:35Z
dc.date.issued2022-04-11
dc.descriptionResearch Areas: Parasitology ; Tropical Medicinept_PT
dc.description.abstractABSTRACT Background: Proteinuria is a common fnding in dogs with leishmaniosis. Although antileishmanial therapeutic protocols are widely implemented, little information is available on which treatments are most adequate for identifying proteinuria in patients with canine leishmaniosis (CanL), especially regarding the use of immunosuppressants. The aim of this study was to explore the current paradigm regarding the antiproteinuric approach adopted by veterinary practitioners in Portugal to treat dogs with CanL. Methods: A questionnaire-based study was developed using Google Forms®. The questionnaire presented a number of diferent hypothetical scenarios of CanL, and the topics surveyed included the general features of the respondents and the protocols preferred by these respondents to manage proteinuria in the presented scenarios, including choice of therapeutic drugs, appropriate diet and use of immunosuppressants, in dogs with immune-mediated glomerulonephritis. The questionnaire was internally prevalidated and difused online over a 2-month period through Portuguese veterinary social networking groups, and data were collected for descriptive analysis. Results: A total of 86 veterinary practitioners responded to the survey. When exposed to theoretical scenarios of proteinuria in dogs with CanL at stages IIb, III and IV (LeishVet guidelines), 16.3%, 62.8% and 93.8% of the respondents, respectively, answered that they would treat it. The dog was started on a renal diet as therapy by 28.6%, 83.3% and 97.4% of respondents, respectively. Angiotensin-converting enzyme inhibitors (ACEI) were prescribed by 100%, 85.2% and 78.9% of respondents as frst-choice drugs for CanL at stages IIb, III and IV, respectively, with ACEI used in monotherapy by 64.3%, 40.7% and 46.1%. In comparison, protocols using ACEI in combination with other compounds were chosen by 7.1%, 33.3% and 39.5% of respondents, and combination therapy which did not include ACEI was the choice of 0.0%, 12.9% and 14.5%. Regarding immunosuppressants, 44.2% of the respondents answered they would prescribe them, with 97.4% electing for prednisolone and 5.3% choosing mycophenolate mofetil. Conclusions: Among the veterinary practitioners who responded, proteinuria treatment was considered since stage IIb CanL, although implementation of a therapeutic approach was more evident in advanced CanL stages. ACEI were the frst-choice drugs, particularly for the treatment of stage IIb CanL; in advanced stages, a combination of antiproteinuric drugs was more often used. Immunosuppressant use was controversial, although when applied, prednisolone was the preferred choice. These fndings reinforce the small body of evidence that supports the use of such drugs and the need to further explore their role in CanL.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMonteiro M, Prata S, Cardoso L, Fonseca IP, Leal RO. 2022. Dogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based study. Parasites & Vectors, 15(1):125. DOI: https://doi.org/10.1186/s13071-022-05222-wpt_PT
dc.identifier.doiDOI10.1186/s13071-022-05222-wpt_PT
dc.identifier.issn1756-3305
dc.identifier.urihttp://hdl.handle.net/10400.5/27324
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relationUIDB/CVT/00772/2020pt_PT
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.relation.publisherversionhttps://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-022-05222-wpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntiproteinuric treatmentpt_PT
dc.subjectCanine leishmaniosispt_PT
dc.subjectDogpt_PT
dc.subjectImmunosuppressantspt_PT
dc.subjectQuestionnaire-based studypt_PT
dc.titleDogs with leishmaniosis: how are we managing proteinuria in daily practice? A Portuguese questionnaire-based studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.citation.conferencePlaceLondon, Englandpt_PT
oaire.citation.titleParasites & Vectorspt_PT
oaire.citation.volumeVolume15(1):125pt_PT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameNunes Eusébio Meneses Monteiro
person.familyNameSoares Pereira da Fonseca de Sampaio
person.familyNameOliveira Leal
person.givenNameMarta
person.givenNameIsabel Maria
person.givenNameRodolfo
person.identifier.ciencia-id0A18-7950-CA4E
person.identifier.ciencia-id2E11-8B3C-5922
person.identifier.ciencia-id061D-C313-B388
person.identifier.orcid0000-0002-6632-1224
person.identifier.orcid0000-0002-2463-4062
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublicatione26076f6-ee7b-4ada-a618-e93401be2c75
relation.isAuthorOfPublication369c7530-1223-4338-9345-98668e36c983
relation.isAuthorOfPublication.latestForDiscovery369c7530-1223-4338-9345-98668e36c983
relation.isProjectOfPublication8563a044-0c86-49a8-a275-8b1bb62cc0d8
relation.isProjectOfPublication.latestForDiscovery8563a044-0c86-49a8-a275-8b1bb62cc0d8

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