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Clinical and neurophysiological evaluation of progression in amyotrophic lateral sclerosis

2003Artigo científico Acesso restrito
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dc.contributor.authorCarvalho, Mamede
dc.contributor.authorScotto, Manuel
dc.contributor.authorLopes, Arminda
dc.contributor.authorSwash, Michael
dc.date.accessioned2021-09-07T13:54:23Z
dc.date.available2021-09-07T13:54:23Z
dc.date.issued2003
dc.description© 2003 Wiley Periodicals, Incpt_PT
dc.description.abstractThere is a need for a sensitive neurophysiological measure of disease progression in following the course of patients with amyotrophic lateral sclerosis (ALS). We studied two groups of nine ALS patients, one with slow progression (Group A) and the other with rapid progression (Group B). We evaluated muscle strength scores using the Medical Research Council (MRC) scale in limb and trunk muscles, forced vital capacity (FVC), and ALS functional rating scale (ALS-FRS) scores. Maximal voluntary isometric contraction (MVIC) of the abductor digiti minimi muscle (ADM) was measured, using a digital device. We also measured M-wave amplitude and area in the ADM, and the distal motor latency and F-wave frequency in the ulnar nerve; from these data, the neurophysiological index (NI) was calculated, as described previously. In both groups, the NI was the most sensitive measure of change, with the smallest coefficient of variation. We conclude that the NI, which requires no special technology and no new clinical or technical skills to use, is sensitive to change, and therefore may be useful in clinical trials, as well as in a clinical setting.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMuscle Nerve. 2003 Nov;28(5):630-633pt_PT
dc.identifier.doi10.1002/mus.10469pt_PT
dc.identifier.eissn1097-4598
dc.identifier.issn0148-639X
dc.identifier.urihttp://hdl.handle.net/10451/49439
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWiley Periodicals, Inc.pt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/10974598pt_PT
dc.subjectAmyotrophic lateral sclerosispt_PT
dc.subjectCompound muscle action potentialpt_PT
dc.subjectDisease progressionpt_PT
dc.subjectMuscle strengthpt_PT
dc.subjectNeurophysiological indexpt_PT
dc.titleClinical and neurophysiological evaluation of progression in amyotrophic lateral sclerosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage633pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage630pt_PT
oaire.citation.titleMuscle & Nervept_PT
oaire.citation.volume28pt_PT
person.familyNamede Carvalho
person.givenNameMamede
person.identifier.orcid0000-0001-7556-0158
person.identifier.scopus-author-id7101893769
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationdd7f55d4-c2b5-4fd2-9bd1-a9542a62f58f
relation.isAuthorOfPublication.latestForDiscoverydd7f55d4-c2b5-4fd2-9bd1-a9542a62f58f

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