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Molecular profiling in neurotypical young adults : (i) mental health stratification and (ii) characterization of the neuronal-salivary proteome and neuropeptide/neuroimmune response
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ENQUADRAMENTO: A biologia molecular representa um método promissor para diagnóstico e screening in vivo de condições neuropsiquiátricas, particularmente devido aos recentes avanços metodológicos de análise das ciências ómicas. Neste trabalho de tese, é explorado a neuropsicofisiologia de jovens indivíduos saudáveis sem doença neuropsiquiátrica ou do neurodesenvolvimento. Para tal, desenvolveu-se uma estratégia que combina saúde mental e estratificação molecular, de forma a definir subtipos de funcionamento, strata ou traços fenotípicos, numa amostra neurotípica. A definição de traços fenotípicos de funcionamento é importante para a adequada investigação de biomarcadores de suscetibilidade. Esta tese clássica é publicada como uma dissertação e é estruturada em duas seções fundamentais: Estratificação de Saúde Mental e Estratificação Molecular, compreendendo três subcapítulos cada. Neste trabalho é apresentado um modelo de estratificação para descrever correlatos mistos de saúde mental e funcionamento molecular, e, para esse efeito, são apresentados diferentes conjuntos de resultados para identificar as sucessivas etapas de caracterização.
SCOPE: Molecular biology represents a promising method for in vivo diagnosis and screening of neuropsychiatric conditions, particularly due to the recent methodological advances in the analytical omics sciences. However, in this thesis, the neuropsychophysiology of healthy young adults without neuropsychiatric or neurodevelopmental conditions is rather explored. For that purpose, a strategy for a combined mental health and molecular stratification was developed, in order to define subtypes of functioning, strata or phenotypic traits, in a neurotypical sample. The definition of these functional subphenomes is important for the adequate research of biomarkers of susceptibility. This classical thesis is published as a dissertation and is structured in two fundamental sections: Mental Health Stratification and Molecular Stratification, comprising three chapters each. In this work, a stratification model to describe mixed correlates of mental health and molecular functioning is presented, and, for that matter, different sets of results were presented to identify the successive stages of characterization.
SCOPE: Molecular biology represents a promising method for in vivo diagnosis and screening of neuropsychiatric conditions, particularly due to the recent methodological advances in the analytical omics sciences. However, in this thesis, the neuropsychophysiology of healthy young adults without neuropsychiatric or neurodevelopmental conditions is rather explored. For that purpose, a strategy for a combined mental health and molecular stratification was developed, in order to define subtypes of functioning, strata or phenotypic traits, in a neurotypical sample. The definition of these functional subphenomes is important for the adequate research of biomarkers of susceptibility. This classical thesis is published as a dissertation and is structured in two fundamental sections: Mental Health Stratification and Molecular Stratification, comprising three chapters each. In this work, a stratification model to describe mixed correlates of mental health and molecular functioning is presented, and, for that matter, different sets of results were presented to identify the successive stages of characterization.
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Resposta neuroimune Jovens adultos neurotípicos Proteoma neuro-salivar Resposta de neuropeptídeos Neurociências Teses de doutoramento - 2021