(1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol

Fortunato, Milene A. G.; Siopa, Filipa; Afonso, Carlos

http://hdl.handle.net/10451/59188

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Autores

Fortunato, Milene A. G.

Siopa, Filipa

Afonso, Carlos

Resumo(s)

Using environmentally friendly conditions, the nucleophilic ring-opening reaction of 6-azabicyclo[3.1.0]hex-3-en-2-ol with 1-methyl-1H-tetrazole-5-thiol provided a novel thiol-incorporated aminocyclopentitol, (1R,4S,5S)-5-((3-hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol, in excellent yield (95%). The newly synthesized compound was analyzed and characterized via 1H, 13C-NMR, HSQC, and mass spectral data.

Palavras-chave

aminocyclopentitol bicyclic aziridine water chemistry nucleophilic substitution

URI

http://hdl.handle.net/10451/59188

Citação

Fortunato M, Siopa F, Afonso C. (1R,4S,5S)-5-((3-Hydroxypropyl)amino)-4-((1-methyl-1H-tetrazol-5-yl)thio)cyclopent-2-en-1-ol. Molbank [Internet]. 2021 Apr 1;2021(2):M1199. Available from: http://dx.doi.org/10.3390/M1199

Editora

MDPI

DOI

10.3390/M1199

Coleções

FF - CiênciaVitae - Faculdade de Farmácia

Licença CC

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