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Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties

2023-07Journal article Open access
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dc.contributor.authorAraújo, Diana
dc.contributor.authorMartins, Matilde
dc.contributor.authorConcórdio-Reis, Patrícia
dc.contributor.authorRoma-Rodrigues, Catarina
dc.contributor.authorMorais, Maria
dc.contributor.authorDelgado Alves, Vitor
dc.contributor.authorFernandes, Alexandra
dc.contributor.authorFreitas, Filomena
dc.date.accessioned2024-07-01T10:53:25Z
dc.date.available2024-07-01T10:53:25Z
dc.date.issued2023-07
dc.description.abstractFucoPol, a fucose-rich polyanionic polysaccharide, was used for the first time for the preparation of hydrogel membranes (HMs) using Fe3+ as a crosslinking agent. This study evaluated the impact of Fe3+ and FucoPol concentrations on the HMs’ strength. The results show that, above 1.5 g/L, Fe3+ concentration had a limited influence on the HMs’ strength, and varying the FucoPol concentration had a more significant effect. Three different FucoPol concentrations (1.0, 1.75 and 2.5 wt.%) were combined with Fe3+ (1.5 g/L), resulting in HMs with a water content above 97 wt.% and an Fe3+ content up to 0.16 wt.%. HMs with lower FucoPol content exhibited a denser porous microstructure as the polymer concentration increased. Moreover, the low polymer content HM presented the highest swelling ratio (22.3 1.8 g/g) and a lower hardness value (32.4 5.8 kPa). However, improved mechanical properties (221.9 10.2 kPa) along with a decrease in the swelling ratio (11.9 1.6 g/g) were obtained for HMs with a higher polymer content. Furthermore, all HMs were non-cytotoxic and revealed anti-inflammatory activity. The incorporation of FucoPol as a structuring agent and bioactive ingredient in the development of HMs opens up new possibilities for its use in tissue engineering, drug delivery and wound care management.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAraújo, D.; Martins, M.; Concórdio-Reis, P.; Roma-Rodrigues, C.; Morais, M.; Alves, V.D.; Fernandes, A.R.; Freitas, F. Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties. Pharmaceuticals 2023, 16, 991.pt_PT
dc.identifier.doi10.3390/ph16070991pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/31202
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationInstitute for Health and Bioeconomy
dc.relationLinking Landscape, Environment, Agriculture and Food
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationInstitute of Nanostructures, Nanomodelling and Nanofabrication
dc.relationTransdermal delivery systems based on natural polymeric biomaterials
dc.relationExoNANOsi - Exosomes as mediators of inter and intra-cellular trafficking of therapeutic gold nanoparticles as vectors for gene silencing
dc.relation.publisherversionhttps://www.mdpi.com/journal/pharmaceuticalspt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjecthydrogel membranespt_PT
dc.subjectFucoPolpt_PT
dc.subjectionotropic gelationpt_PT
dc.subjectbiocompatibilitypt_PT
dc.subjectanti-inflammatory activitypt_PT
dc.titleNovel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleLinking Landscape, Environment, Agriculture and Food
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleInstitute of Nanostructures, Nanomodelling and Nanofabrication
oaire.awardTitleTransdermal delivery systems based on natural polymeric biomaterials
oaire.awardTitleExoNANOsi - Exosomes as mediators of inter and intra-cellular trafficking of therapeutic gold nanoparticles as vectors for gene silencing
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oaire.citation.issue7pt_PT
oaire.citation.startPage991pt_PT
oaire.citation.titlePharmaceuticalspt_PT
oaire.citation.volume16pt_PT
oaire.fundingStream6817 - DCRRNI ID
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person.familyNameDelgado Alves
person.givenNameVitor
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person.identifier.ciencia-id2E1E-6918-4DB3
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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