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A first report on the efficacy of a single intra-articular administration of blood cell secretome, triamcinolone acetonide, and the combination of both in dogs with osteoarthritis

2022-08-13Journal article Open access
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dc.contributor.authorAlves, JC
dc.contributor.authorSantos, A
dc.contributor.authorJorge, P
dc.contributor.authorCarreira, L.Miguel
dc.date.accessioned2023-01-22T22:05:26Z
dc.date.available2023-01-22T22:05:26Z
dc.date.issued2022-08-13
dc.descriptionResearch Areas: Veterinary Sciencespt_PT
dc.description.abstractBackground: Osteoarthritis represents a signifcant welfare problem for many dogs, with limited therapeutic options other than palliative pain control. To evaluate the efect of the intra-articular administration of blood cell secretome and triamcinolone, 15 dogs with bilateral hip osteoarthritis were randomly assigned to a blood cell secretome (BCSG, n=5), triamcinolone (TG) or their combination group (BCS+TG, n=5). BCSG received a single intra-articular administration of 3 ml of blood cell secretome, TG 0.5 ml of triamcinolone acetonide 40 mg/ml, and BCS+TG received the combined products. The volume to administrate was corrected to 3.5 ml with saline. On days 0, 8, 15, 30, 60, 90, 120, 150, and 180, a copy of the Canine Brief Pain Inventory (divided into pain interference score—PIS and Pain Severity Score—PSS), Liverpool Osteoarthritis in Dogs (LOAD), Hudson Visual Analogue Scale (HVAS), and Canine Orthopedic Index (COI, divided into function, gait, stifness, and quality of life) was completed. Results were analyzed with the Kruskal–Wallis test and the Kaplan–Meier estimators were conducted and compared with the Log Rank test, p<0.05. Results: Animals in the sample had a mean age of 9.0±2.9 years and a bodyweight of 28.8±4.1 kg. Hips were classifed as moderate (8) and severe (7) osteoarthritis. No diferences were found between groups at T0 regarding considered evaluations. Signifcant diferences were observed between groups in pain scores from+8d-+150d, with BCS+TG exhibiting better results. The same was observed for HVAS and LOAD, from+8d-+120d. Improvements were also observed in several dimensions of the COI. Kaplan–Meier estimators showed that BCS+TG produced longer periods with better results, followed by BCSG and TG. Conclusion: The intra-articular administration of blood cell secretome improved the clinical signs and scores of several clinical metrology instruments in dogs with hip OA, particularly when combined with triamcinolone. Further studies are required.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAlves JC, Santos A, Jorge P, Carreira LM. 2022. A first report on the efficacy of a single intra-articular administration of blood cell secretome, triamcinolone acetonide, and the combination of both in dogs with osteoarthritis. BMC Veterinary Research, 18(1):309. DOI: 10.1186/s12917-022-03413-2pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/26982
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMCpt_PT
dc.relation.publisherversionhttps://bmcvetres.biomedcentral.com/articles/10.1186/s12917-022-03413-2pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectBlood cell secretomept_PT
dc.subjectTriamcinolonept_PT
dc.subjectDogpt_PT
dc.subjectOsteoarthritispt_PT
dc.subjectPainpt_PT
dc.subjectHippt_PT
dc.titleA first report on the efficacy of a single intra-articular administration of blood cell secretome, triamcinolone acetonide, and the combination of both in dogs with osteoarthritispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.conferencePlaceLondon, Englandpt_PT
oaire.citation.titleBMC Veterinary Researchpt_PT
oaire.citation.volume18(1):309pt_PT
person.familyNameCarreira
person.givenNameLuis Miguel
person.identifier.ciencia-idFD14-B321-EACD
person.identifier.orcid0000-0002-6784-2806
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3757a9f0-ab19-4225-bd5d-d68d19ec743a
relation.isAuthorOfPublication.latestForDiscovery3757a9f0-ab19-4225-bd5d-d68d19ec743a

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