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Rare HIV-1 subtype J genomes and a new H/U/CRF02-AG recombinant genome suggests an ancient origin of HIV-1 in Angola

2016Journal article Open access
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dc.contributor.authorBártolo, Inês
dc.contributor.authorCalado, Rita
dc.contributor.authorBorrego, Pedro
dc.contributor.authorLeitner, Thomas
dc.contributor.authorTaveira, Nuno
dc.date.accessioned2023-08-23T17:25:16Z
dc.date.available2023-08-23T17:25:16Z
dc.date.issued2016
dc.date.updated2023-02-03T14:28:01Z
dc.description.abstractAngola has an extremely diverse HIV-1 epidemic fueled in part by the frequent interchange of people with the Democratic Republic of Congo (DRC) and Republic of Congo (RC). Characterization of HIV-1 strains circulating in Angola should help to better understand the origin of HIV-1 subtypes and recombinant forms and their transmission dynamics. In this study we characterize the first near full-length HIV-1 genomic sequences from HIV-1 infected individuals from Angola. Samples were obtained in 1993 from three HIV-1 infected patients living in Cabinda, Angola. Near full-length genomic sequences were obtained from virus isolates. Maximum likelihood phylogenetic tree inference and analyses of potential recombination patterns were performed to evaluate the sequence classifications and origins. Phylogenetic and recombination analyses revealed that one virus was a pure subtype J, another mostly subtype J with a small uncertain region, and the final virus was classified as a H/U/CRF02_AG recombinant. Consistent with their epidemiological data, the subtype J sequences were more closely related to each other than to other J sequences previously published. Based on the env gene, taxa from Angola occur throughout the global subtype J phylogeny. HIV-1 subtypes J and H are present in Angola at low levels since at least 1993. Low transmission efficiency and/or high recombination potential may explain their limited epidemic success in Angola and worldwide. The high diversity of rare subtypes in Angola suggests that Angola was part of the early establishment of the HIV-1 pandemic.pt_PT
dc.description.sponsorshipFinancial support for this research was provided by the Fundação para a Ciência e a Tecnologia (FCT), Portugal (project PTDC/SAU-EPI/122400/2010), part of the EDCTP2 program supported by the European Union. Rita Calado is supported by Fundação para a Ciência e a Tecnologia (FCT), Portugal (grant no. SFRH/BD/70715/2010). I.B. was supported by the Fundação para a Ciência e a Tecnologia (FCT), Portugal (grant no. SFRH/BPD/76225/2011). Thomas Leitner was supported by the National Institutes of Health (NIH), USA (grant no. R01AI087520).pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationBártolo I, Calado R, Borrego P, Leitner T, Taveira N. Rare hiv-1 subtype j genomes and a new h/u/crf02_ag recombinant genome suggests an ancient origin of hiv-1 in angola. AIDS Research and Human Retroviruses [Internet]. agosto de 2016;32(8):822–8. Disponível em: https://www.liebertpub.com/doi/10.1089/aid.2016.0084pt_PT
dc.identifier.doi10.1089/aid.2016.0084pt_PT
dc.identifier.eid2-s2.0-84979977763
dc.identifier.slugcv-prod-1108455
dc.identifier.urihttp://hdl.handle.net/10451/58977
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMary Ann Liebert, Inc.pt_PT
dc.relationMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
dc.relationDEVELOPMENT AND PRE-CLINICAL EVALUATION OF A NEW HIV-1 VACCINE CONCEPT
dc.relationDESENVOLVIMENTO DE NOVOS MICROBICIDAS PARA PREVENIR A INFECÇÃO POR VIH
dc.relation.publisherversionhttps://www.liebertpub.com/doi/10.1089/aid.2016.0084pt_PT
dc.titleRare HIV-1 subtype J genomes and a new H/U/CRF02-AG recombinant genome suggests an ancient origin of HIV-1 in Angolapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMolecular epidemiology, drug resistance and pathogenesis of HIV and TB in Angola: the Angolan PErinatal HIV Cohort (APEHC)
oaire.awardTitleDEVELOPMENT AND PRE-CLINICAL EVALUATION OF A NEW HIV-1 VACCINE CONCEPT
oaire.awardTitleDESENVOLVIMENTO DE NOVOS MICROBICIDAS PARA PREVENIR A INFECÇÃO POR VIH
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-EPI%2F122400%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F70715%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F76225%2F2011/PT
oaire.citation.endPage828pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage822pt_PT
oaire.citation.titleAIDS Research and Human Retrovirusespt_PT
oaire.citation.volume32pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameBártolo
person.familyNameAlmeida Calado
person.familyNameBorrego
person.familyNameLeitner
person.familyNameTaveira
person.givenNameInês
person.givenNameRita Diogo
person.givenNamePedro
person.givenNameThomas
person.givenNameNuno
person.identifier.ciencia-id661E-F5CB-F85A
person.identifier.ciencia-idAA18-62FA-B4B3
person.identifier.ciencia-idA71C-0177-722F
person.identifier.ciencia-id7111-3383-A926
person.identifier.orcid0000-0002-2022-8921
person.identifier.orcid0000-0002-2519-7917
person.identifier.orcid0000-0002-1949-9484
person.identifier.orcid0000-0001-8160-2588
person.identifier.orcid0000-0003-0176-5585
person.identifier.ridH-6968-2013
person.identifier.scopus-author-id25225039400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid661E-F5CB-F85A | Inês Bártolo
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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