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Brucella ceti in Common Dolphins (Delphinus delphis) in Portugal—Characterization of First Isolates

2025-01Journal article Open access
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dc.contributor.authorCavaco, Sandra
dc.contributor.authorGrilo, Miguel L.
dc.contributor.authorDias, Ricardo
dc.contributor.authorM., Nunes
dc.contributor.authorPascoal, Pedro
dc.contributor.authorPereira, Marcelo
dc.contributor.authorFogaça, Catarina
dc.contributor.authorCosta, Ana Beatriz
dc.contributor.authorPardal, Sofia
dc.contributor.authorFerreira, Ana Cristina
dc.date.accessioned2025-04-14T12:28:57Z
dc.date.available2025-04-14T12:28:57Z
dc.date.issued2025-01
dc.description.abstractThis study investigates Brucella ceti infection in marine mammals stranded along the Lisbon and Tagus Valley coast between 2022 and mid-2024, marking the first report of Brucella presence in Portuguese waters. Out of 59 examined marine mammals, B. ceti was isolated in three common dolphins (5.1%), a prevalence rate consistent with previous studies from other coastlines. PCR-based detection indicated a higher infection rate (23.7%), suggesting an underestimation of the prevalence of B. ceti infection in this population. Multi-locus Sequence Typing (MLST) and Multiple-Locus Variable-Number Tandem-Repeat Analysis (MLVA) revealed distinct genetic profiles and close relationships to B. ceti strains from the Atlantic, supporting the hypothesis of specific host-adapted lineages in dolphins. Virulence genes, including those for host interaction (bspE, btpB) and intracellular survival (virB7, vceA), were consistent across isolates, highlighting the pathogenic potential. Additionally, antimicrobial resistance (AMR) genes, such as mprF and efflux proteins (bepC-G), were also identified. These findings underscore the need for further research and surveillance to understand B. ceti transmission, host range, and impacts on Atlantic cetaceans, as well as to develop effective diagnostic and management strategies to mitigate infection risks in marine environments.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCavaco S, Grilo ML, Dias R, Nunes M, Pascoal P, Pereira M, Fogaça C, Costa AB, Pardal S, Ferreira AC. Brucella ceti in Common Dolphins (Delphinus delphis) in Portugal-Characterization of First Isolates. Animals (Basel). 2025 Jan 28;15(3):374. doi: 10.3390/ani15030374.pt_PT
dc.identifier.doi10.3390/ani15030374pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/100186
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationUID/04046/2025 Center grant from Fundação para a Ciência e a Tecnologia, Portugal (to BioISI), and Ce3C under grant number UIDB/00329/2020pt_PT
dc.relationHorizon 2020, grant number 773830.pt_PT
dc.relationFundo Ambiental, under a financial and technical cooperation agreement between Fundo Ambiental, ISPA IU and ICNFpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAtlantic Seapt_PT
dc.subjectBrucella cetipt_PT
dc.subjectcetaceanspt_PT
dc.subjectcomparative genomicspt_PT
dc.subjectinfection surveillancept_PT
dc.subjectmarine environment healthpt_PT
dc.subjectPortugalpt_PT
dc.titleBrucella ceti in Common Dolphins (Delphinus delphis) in Portugal—Characterization of First Isolatespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.startPage374pt_PT
oaire.citation.titleAnimalspt_PT
oaire.citation.volume15pt_PT
person.familyNameNunes Dias
person.familyNameClaudino Nunes
person.givenNameRicardo Alexandre
person.givenNameMónica Susana
person.identifierH-4883-2015
person.identifier.ciencia-idF91E-0978-5208
person.identifier.ciencia-id7113-7A43-39F1
person.identifier.orcid0000-0002-6559-727X
person.identifier.orcid0000-0001-5034-5494
person.identifier.scopus-author-id24759215400
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication0d96d879-77bd-40bb-af61-51072831a895
relation.isAuthorOfPublication50eacfd2-e9c2-4804-ad02-f90d4ae8cf4c
relation.isAuthorOfPublication.latestForDiscovery50eacfd2-e9c2-4804-ad02-f90d4ae8cf4c

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