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Meeting the needs of breast cancer: a nucleolin’s perspective

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dc.contributor.authorGregório, Ana C.
dc.contributor.authorLacerda, Manuela
dc.contributor.authorFigueiredo, Paulo
dc.contributor.authorSimões, Sérgio
dc.contributor.authorDias, Sérgio
dc.contributor.authorMoreira, João Nuno
dc.date.accessioned2021-02-19T18:04:39Z
dc.date.available2021-02-19T18:04:39Z
dc.date.issued2018
dc.description© 2018 Elsevier B.V. All rights reserved.pt_PT
dc.description.abstractA major challenge in the management of breast cancer disease has been the development of metastases. Finding new molecular targets and the design of targeted therapeutic approaches to improve the overall survival and quality of life of these patients is, therefore, of great importance. Nucleolin, which is overexpressed in cancer cells and tumor-associated blood vessels, have been implicated in various processes supporting tumorigenesis and angiogenesis. Additionally, its overexpression has been demonstrated in a variety of human neoplasias as an unfavorable prognostic factor, associated with a high risk of relapse and low overall survival. Hence, nucleolin has emerged as a relevant target for therapeutic intervention in cancer malignancy, including breast cancer. This review focus on the contribution of nucleolin for cancer disease and on the development of therapeutic strategies targeting this protein. In this respect, it also provides a critical analysis about the potential and pitfalls of nanomedicine for cancer therapy.pt_PT
dc.description.sponsorshipAna Cristina Leal Gregório is student of the international PhD program in Experimental Biology and Biomedicine (PDBEB) from the Institute for Interdisciplinary Research, University of Coimbra and recipient of the fellowship SFRH/BD/51190/2010 from the Portuguese Foundation for Science and Technology (FCT). The work was supported by the grants PTDC/SAU-BMA/121028/2010, QREN/FEDER MultiNanoMed (Ref: 23240), by the European Regional Development Fund (ERDF) through COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation and Portuguese national funds via FCT, under the project POCI-01-0145-FEDER-007440pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCrit Rev Oncol Hematol. 2018 May;125:89-101pt_PT
dc.identifier.doi10.1016/j.critrevonc.2018.03.008pt_PT
dc.identifier.eissn1879-0461
dc.identifier.issn1040-8428
dc.identifier.urihttp://hdl.handle.net/10451/46449
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationPOCI-01-0145-FEDER-007440pt_PT
dc.relationTHERAPEUTIC ACTIVITY OF A TARGETED DRUG DELIVERY APPROACH ON TUMOR METASTASIZATION
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/critical-reviews-in-oncology-hematologypt_PT
dc.subjectBreast cancerpt_PT
dc.subjectMolecular targetpt_PT
dc.subjectNucleolinpt_PT
dc.subjectOncologypt_PT
dc.subjectTargeted therapypt_PT
dc.titleMeeting the needs of breast cancer: a nucleolin’s perspectivept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTHERAPEUTIC ACTIVITY OF A TARGETED DRUG DELIVERY APPROACH ON TUMOR METASTASIZATION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F51190%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FSAU-BMA%2F121028%2F2010/PT
oaire.citation.endPage101pt_PT
oaire.citation.startPage89pt_PT
oaire.citation.titleCritical Reviews in Oncology/Hematologypt_PT
oaire.citation.volume125pt_PT
oaire.fundingStreamCOMPETE
person.familyNameDias
person.givenNameSérgio
person.identifier.ciencia-idFB10-2BA3-ACEB
person.identifier.orcid0000-0002-7603-4616
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
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