Logo do repositório
 
Publicação

Probiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome era

2021Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorFerro, Margarida
dc.contributor.authorCharneca, Sofia
dc.contributor.authorDourado, Eduardo
dc.contributor.authorGuerreiro, Catarina Sousa
dc.contributor.authorFonseca, João Eurico
dc.date.accessioned2021-10-28T14:32:59Z
dc.date.available2021-10-28T14:32:59Z
dc.date.issued2021
dc.descriptionCopyright © 2021 Ferro, Charneca, Dourado, Guerreiro and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.pt_PT
dc.description.abstractRheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease that ultimately leads to joint destruction and functional disability. Although the exact etiology of RA is not fully understood, it is well established that gut microbiota (GM) plays a vital role in the pathogenesis of RA, with accumulating evidence suggesting that gut dysbiosis induces a chronic inflammatory response that may be linked to disease development. Of interest, patients with RA have significant changes in the intestinal microbiota compared to healthy controls, and several studies have suggested the use of probiotics as a possible adjuvant therapy for RA. Benefits of probiotic supplementation were reported in animal models of arthritis and human studies, but the current evidence regarding the effect of probiotic supplementation in the management of RA remains insufficient to make definite recommendations. Several different strains of Lactobacillus and Bifidobacteria, as single species or in mixed culture, have been investigated, and some have demonstrated beneficial effects on disease activity in RA human subjects. As of now, L.casei probiotic bacteria seems to be the strongest candidate for application as adjuvant therapy for RA patients. In this review, we highlight the role of GM in the development and progression of RA and summarize the current knowledge on the use of probiotics as a potential adjuvant therapy for RA. We also review the proposed mechanisms whereby probiotics regulate inflammation. Finally, the role of fermented foods is discussed as a possible alternative to probiotic supplements since they have also been reported to have health benefits.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFront Pharmacol. 2021 Jul 23;12:711788pt_PT
dc.identifier.doi10.3389/fphar.2021.711788pt_PT
dc.identifier.eissn1663-9812
dc.identifier.urihttp://hdl.handle.net/10451/50049
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/journals/pharmacology#pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAutoimmunitypt_PT
dc.subjectDysbiosispt_PT
dc.subjectFermented foodspt_PT
dc.subjectInflammationpt_PT
dc.subjectRheumatologypt_PT
dc.titleProbiotic supplementation for Rheumatoid Arthritis: a promising adjuvant therapy in the gut microbiome erapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleFrontiers in Pharmacologypt_PT
oaire.citation.volume12pt_PT
person.familyNameFerro
person.familyNameDOURADO DOMINGUES
person.familyNamesousa guerreiro
person.familyNameFonseca
person.givenNameMargarida
person.givenNameEDUARDO JORGE
person.givenNamecatarina
person.givenNameJoão
person.identifier.ciencia-idB111-4ED5-F8E6
person.identifier.ciencia-id531B-BA03-FCA0
person.identifier.ciencia-id311F-89E5-532C
person.identifier.ciencia-idF310-B85D-57C7
person.identifier.orcid0000-0002-7549-2391
person.identifier.orcid0000-0003-2186-2833
person.identifier.orcid0000-0002-8730-6517
person.identifier.orcid0000-0003-1432-3671
person.identifier.scopus-author-id7101983519
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication08686949-1e8c-482a-8078-ce208285cb1a
relation.isAuthorOfPublication6ea62930-47c0-4ac2-a51c-7122f1f570a5
relation.isAuthorOfPublicationcd573b0e-731c-474b-b158-6d9cf011289b
relation.isAuthorOfPublication1772dc12-7c55-4c76-ae2d-c23270172480
relation.isAuthorOfPublication.latestForDiscovery6ea62930-47c0-4ac2-a51c-7122f1f570a5

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Probiotic_supplementation.pdf
Tamanho:
1.42 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IMM - Artigos em Revistas Internacionais
FM-CUR-Artigos em Revistas Internacionais
FM-ISAMB-Artigos em Revistas Internacionais
FM-LN-Artigos em Revistas Internacionais