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Long-term prognostic value of protein C activity, erythrocyte aggregation and membrane fluidity in transmural myocardial infarction

2005-08Journal article Restricted access
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dc.contributor.authorSargento, Luis
dc.contributor.authorSaldanha, Carlota
dc.contributor.authorMonteiro, José
dc.contributor.authorPerdigão, Carlota
dc.contributor.authorMartins e Silva, João
dc.date.accessioned2021-06-11T16:11:24Z
dc.date.available2021-06-11T16:11:24Z
dc.date.issued2005-08
dc.description© 2005 Schattauer GmbH, Stuttgartpt_PT
dc.description.abstractThe objective of this study was to evaluate the long-term predictive value of the haemostatic, inflammatory and haemorheologic disturbances in transmural myocardial infarction (MI). Sixty-four (59 male) consecutive survivors of a MI, with a mean age of 58.3 +/- 12.0 years, were followed over a period of 36 months. Eighteen patients had a cardiovascular event defined as the composite of death, non-fatal MI, unstable angina and stroke. The haemostatic (protein C activity-PtC, antithrombin III, plasminogen activator inhibitor-1), haemorheologic (blood fluidity and components, erythrocyte membrane fluidity) and inflammatory (polymorphonuclear elastase, leukocyte count) profiles were determined at hospital discharge, using standard methodology. Our results can be summarized as follow: (i) at hospital discharge, the subgroup of patients with events had higher leukoactivity, leukocyte count, membrane fluidity, prognosis cyte count (7833.0 +/- 1696.0 vs. 10294.0 +/- 3129.0; p = 0.011), lower PtC (100.65 +/- 19.08 vs.81.25 +/- 19.95; p = 0.002), and lower erythrocyte aggregation (14.26 +/- 5.94 vs. 11.47 +/- 3.45; p = 0.031) in relation to the ones without events; (ii) By Cox regression the protein C activity lower tertile (OR 0.169; 0.045-0.628; p = 0.008); erythrocyte membrane outer layer fluidity upper tertile (OR 0.067; 95% CI 0.011 - 0.393; p = 0.003); and erythrocyte aggregation lower tertile (OR 0.182; 0.038 - 0.876; p = 0.034) were independent predictors of the composite endpoint. We can conclude that some haemostatic, haemorheologic and inflammatory disturbances, at hospital discharge, are long-term independent predictors of recurrent cardiovascular events in transmural myocardial infarction survivors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationThromb Haemost. 2005 Aug;94(2):380-388pt_PT
dc.identifier.doi10.1160/TH04-12-0791pt_PT
dc.identifier.eissn2567-689X
dc.identifier.issn0340-6245
dc.identifier.urihttp://hdl.handle.net/10451/48468
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThiemept_PT
dc.relation.publisherversionhttps://www.thieme.com/books-main/internal-medicine/product/4432-thrombosis-and-haemostasispt_PT
dc.relation.publisherversionhttps://www.thieme-connect.com/products/ejournals/abstract/10.1160/TH04-12-0791pt_PT
dc.subjectAcute myocardial infarctionpt_PT
dc.subjectErythrocyte aggregationpt_PT
dc.subjectProtein C activitypt_PT
dc.subjectLeukocyte countpt_PT
dc.subjectMembrane fluiditypt_PT
dc.subjectPrognosispt_PT
dc.titleLong-term prognostic value of protein C activity, erythrocyte aggregation and membrane fluidity in transmural myocardial infarctionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage388pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage380pt_PT
oaire.citation.titleThrombosis and Haemostasispt_PT
oaire.citation.volume94pt_PT
person.familyNameSargento
person.familyNameSaldanha
person.givenNameLuis
person.givenNameCarlota
person.identifier53901
person.identifier.orcid0000-0002-9654-4875
person.identifier.orcid0000-0002-5058-2112
person.identifier.scopus-author-id56005988800
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione2adbe63-0cc8-42a7-b1d4-8f3665cb9c27
relation.isAuthorOfPublicationad6de30c-87ca-4613-bb87-488dd5d285d0
relation.isAuthorOfPublication.latestForDiscoverye2adbe63-0cc8-42a7-b1d4-8f3665cb9c27

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