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A randomized controlled preclinical trial on 3 interposal temporomandibular joint disc implants: TEMPOJIMS—Phase 2

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dc.contributor.authorÂngelo, David
dc.contributor.authorWang, Yadong
dc.contributor.authorMorouço, Pedro
dc.contributor.authorMonje, Florencio
dc.contributor.authorMónico, Lisete
dc.contributor.authorGonzález‐Garcia, Raúl
dc.contributor.authorMoura, Carla
dc.contributor.authorAlves, Nuno
dc.contributor.authorSanz, David
dc.contributor.authorGao, Jin
dc.contributor.authorSousa, Rita
dc.contributor.authorLucas Neto, Lia
dc.contributor.authorFaísca, Pedro
dc.contributor.authorSalvado, Francisco
dc.contributor.authorLópez Peña, Monica
dc.contributor.authorPermuy, Maria
dc.contributor.authorMunñoz, Fernando
dc.date.accessioned2021-08-16T10:32:39Z
dc.date.available2021-08-16T10:32:39Z
dc.date.issued2021
dc.description© 2021 John Wiley & Sons Ltd.pt_PT
dc.description.abstractThe effort to develop an effective and safe temporomandibular joint (TMJ) disc substitute has been one of the mainstreams of tissue engineering. Biodegradable customized scaffolds could approach safety and effectiveness to regenerate a new autologous disc, rather than using non-biodegradable materials. However, it is still technically challenging to mimic the biomechanical properties of the native disc with biodegradable polymers. In this study, new 3D tailored TMJ disc implants were developed: (1) Poly(glycerol sebacate) (PGS) scaffold reinforced with electrospun Poly(εcaprolactone) (PCL) fibers on the outer surface (PGS+PCL); (2) PCL and polyethylene glycol diacrylate (PEGDA) (PCL+PEGDA); and (3) PCL. The TMJ implants were tested in a randomized preclinical trial, conducted in 24 black Merino sheep TMJ, perfoming bilateral interventions. Histologic, imaging, and kinematics analysis was performed. No statistical changes were observed between the PGS+PCL disc and the control group. The PCL+PEGDA and PCL groups were associated with statistical changes in histology (p = 0.004 for articular cartilage mid-layer; p = 0.019 for structure changes and p = 0.017 for cell shape changes), imaging (p = 0.027 for global appreciation) and dangerous material fragmentation was observed. No biomaterial particles were observed in the multi-organ analysis in the different groups. The sheep confirmed to be a relevant animal model for TMJ disc surgery and regenerative approaches. The PCL and PCL+PEGDA discs presented a higher risk to increase degenerative changes, due to material fragmentation. None of the tested discs regenerate a new autologous disc, however, PGS+PCL was safe, demonstrated rapid resorption, and was capable to prevent condyle degenerative changes.pt_PT
dc.description.sponsorshipThis work was supported by European Regional Development Fund—Centro2020 through the Project reference: BIODISCUS (CENTRO‐01‐0247‐FEDER‐039969).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Tissue Eng Regen Med. 2021;1–17pt_PT
dc.identifier.doi10.1002/term.3230pt_PT
dc.identifier.eissn1932-7005
dc.identifier.issn1932-6254
dc.identifier.urihttp://hdl.handle.net/10451/49307
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sonspt_PT
dc.relationCENTRO‐01‐0247‐FEDER‐039969pt_PT
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/journal/19327005pt_PT
dc.subjectBiomaterialspt_PT
dc.subjectPreclinical researchpt_PT
dc.subjectSheeppt_PT
dc.subjectTemporomandibular joint discpt_PT
dc.subjectTemporomandibular joint disorderspt_PT
dc.subjectTissue engineeringpt_PT
dc.titleA randomized controlled preclinical trial on 3 interposal temporomandibular joint disc implants: TEMPOJIMS—Phase 2pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage17pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleJournal of Tissue Engineering and Regenerative Medicinept_PT
person.familyNameÂngelo
person.familyNameSousa
person.familyNameLucas Neto
person.familyNameSalvado
person.givenNameDavid
person.givenNameRita
person.givenNameLia
person.givenNameFrancisco João
person.identifier1047141
person.identifier.ciencia-id2C1B-F1D5-5A08
person.identifier.ciencia-id6911-9043-B80D
person.identifier.ciencia-idA419-CBD5-656A
person.identifier.orcid0000-0001-8411-9946
person.identifier.orcid0000-0002-6096-8182
person.identifier.orcid0000-0001-7880-9625
person.identifier.orcid0000-0002-1095-8090
person.identifier.ridD-2545-2018
person.identifier.scopus-author-id6508237629
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication17926c30-4672-46f2-a819-657463e3c725
relation.isAuthorOfPublication79a4bc80-4fd2-470b-8ef1-068cc3aa1107
relation.isAuthorOfPublication0b63fa05-b3db-4a82-9308-0a2bc03d326e
relation.isAuthorOfPublication8b961b0c-ea2a-4ea8-852b-ab9dc6640b0c
relation.isAuthorOfPublication.latestForDiscovery8b961b0c-ea2a-4ea8-852b-ab9dc6640b0c

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