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Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation

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dc.contributor.authorGodinho-Silva, Cristina
dc.contributor.authorMarques, Sofia
dc.contributor.authorFontinha, Diana
dc.contributor.authorVeiga-Fernandes, Henrique
dc.contributor.authorStevenson, Philip G.
dc.contributor.authorSimas, J Pedro
dc.date.accessioned2022-02-10T17:22:37Z
dc.date.available2022-02-10T17:22:37Z
dc.date.issued2014
dc.descriptionCopyright: © 2014 Godinho-Silva et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.pt_PT
dc.description.abstractPersistent infections are subject to constant surveillance by CD8+ cytotoxic T cells (CTL). Their control should therefore depend on MHC class I-restricted epitope presentation. Many epitopes are described for γ-herpesviruses and form a basis for prospective immunotherapies and vaccines. However the quantitative requirements of in vivo immune control for epitope presentation and recognition remain poorly defined. We used Murid Herpesvirus-4 (MuHV-4) to determine for a latently expressed viral epitope how MHC class-I binding and CTL functional avidity impact on host colonization. Tracking MuHV-4 recombinants that differed only in epitope presentation, we found little latitude for sub-optimal MHC class I binding before immune control failed. By contrast, control remained effective across a wide range of T cell functional avidities. Thus, we could define critical engagement thresholds for the in vivo immune control of virus-driven B cell proliferation.pt_PT
dc.description.sponsorshipJPS was funded by Fundação para a Ciência e Tecnologia (PTDC/SAU-MII/099314/2008); HMSP-ICT/0021/2010) Portugal. CGS, SM, and DF were supported by scholarships from Fundação para a Ciência e Tecnologia, Portugal. PGS is an ARC Future Fellow.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPLoS Pathog. 2014 Jun 26;10(6):e1004220pt_PT
dc.identifier.doi10.1371/journal.ppat.1004220pt_PT
dc.identifier.eissn1553-7374
dc.identifier.issn1553-7366
dc.identifier.urihttp://hdl.handle.net/10451/51219
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLOSpt_PT
dc.relation.publisherversionhttps://journals.plos.org/plospathogens/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleDefining immune engagement thresholds for in vivo control of virus-driven lymphoproliferationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPTDC/SAU-MII/099314/2008
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-MII%2F099314%2F2008/PT
oaire.citation.issue6pt_PT
oaire.citation.startPagee1004220pt_PT
oaire.citation.titlePLoS Pathogenspt_PT
oaire.citation.volume10pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameGodinho-Silva
person.familyNameMarques
person.familyNameFontinha
person.familyNameVeiga-Fernandes
person.familyNameSimas
person.givenNameCristina
person.givenNameSofia
person.givenNameDiana
person.givenNameHenrique
person.givenNameJ Pedro
person.identifier.ciencia-id201E-7D43-52AA
person.identifier.ciencia-id6A17-C404-F33B
person.identifier.ciencia-idC919-1B92-794F
person.identifier.ciencia-id3513-BF02-52B7
person.identifier.orcid0000-0002-0300-8839
person.identifier.orcid0000-0003-1467-1529
person.identifier.orcid0000-0002-0046-648X
person.identifier.orcid0000-0001-6216-1836
person.identifier.orcid0000-0001-6982-9253
person.identifier.scopus-author-id56096790600
person.identifier.scopus-author-id7004641665
person.identifier.scopus-author-id6508113770
person.identifier.scopus-author-id7003457329
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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