Publication
Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application
| dc.contributor.author | Carriço, Catarina | |
| dc.contributor.author | Pinto, Pedro | |
| dc.contributor.author | Graça, Angélica | |
| dc.contributor.author | Gonçalves, Lídia | |
| dc.contributor.author | Ribeiro, Helena | |
| dc.contributor.author | Marto, Joana | |
| dc.date.accessioned | 2024-01-19T18:44:56Z | |
| dc.date.available | 2024-01-19T18:44:56Z | |
| dc.date.issued | 2019-03 | |
| dc.date.updated | 2023-02-27T18:48:28Z | |
| dc.description | © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | pt_PT |
| dc.description.abstract | Quercus Suber Bark from Quercus suber L. is a natural, renewable and biodegradable biomaterial with multifunctional proprieties. In this study, we used it as solid particles to stabilize a Pickering emulsion. The main goal was to produce an optimized topical formulation using biocompatible organic particles as stabilizers of the emulsion instead of the common surfactants, whilst benefiting from Quercus suber L. proprieties. In this work, a Quality by Design (QbD) approach was successfully applied to the production of this emulsion. A screening design was conducted, identifying the critical variables of the formula and process, affecting the critical quality attributes of the emulsion (droplet size distribution). The optimization of the production was made through the establishment of the design space. The stability was also investigated during 30 days, demonstrating that Quercus Suber Bark-stabilized emulsions are stable since the droplet size distribution lowers. In vitro studies were performed to assess antioxidant and antiaging efficacy, which revealed that the formulation had indeed antioxidant proprieties. A physicochemical characterization demonstrated that the formulation presents a shear-thinning fluid, ideal for topical administration. The in vivo compatibility study confirmed that the final formulation is not skin irritant, being safe for human use. A sensorial analysis was also performed, using a simple sensory questionnaire, revealing very positive results. Thus, the use of Quercus Suber Bark particles as a multifunctional solid ingredient contributed to achieve a stable, effective and innovative Pickering emulsion with a meaningful synergistic protection against oxidative stress. | pt_PT |
| dc.description.sponsorship | This research was funded by Fundação para a Ciência e a Tecnologia, Portugal (UID/DTP/04138/2013 and PTDC/MEC-DER/30198/2017). | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Carriço C, Pinto P, Graça A, Gonçalves L, Ribeiro H, Marto J. Design and characterization of a new quercus suber-based pickering emulsion for topical application. Pharmaceutics [Internet]. 19 de março de 2019;11(3):131. Disponível em: https://www.mdpi.com/1999-4923/11/3/131 | pt_PT |
| dc.identifier.doi | 10.3390/pharmaceutics11030131 | pt_PT |
| dc.identifier.eid | 2-s2.0-85068356545 | |
| dc.identifier.slug | cv-prod-535036 | |
| dc.identifier.uri | http://hdl.handle.net/10451/61996 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | MDPI | pt_PT |
| dc.relation | Research Institute for Medicines | |
| dc.relation.publisherversion | https://www.mdpi.com/1999-4923/11/3/131 | pt_PT |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
| dc.subject | Quercus suber L. | pt_PT |
| dc.subject | Quercus Suber Bark particles | pt_PT |
| dc.subject | Pickering emulsion | pt_PT |
| dc.subject | anti-oxidant activity | pt_PT |
| dc.subject | Quality by Design approach | pt_PT |
| dc.title | Design and Characterization of a New Quercus Suber-Based Pickering Emulsion for Topical Application | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardTitle | Research Institute for Medicines | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04138%2F2013/PT | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017/PTDC%2FMEC-DER%2F30198%2F2017/PT | |
| oaire.citation.issue | 3 | pt_PT |
| oaire.citation.startPage | 131 | pt_PT |
| oaire.citation.title | Pharmaceutics | pt_PT |
| oaire.citation.volume | 11 | pt_PT |
| oaire.fundingStream | 6817 - DCRRNI ID | |
| oaire.fundingStream | Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017 | |
| person.familyName | Capêlo Contreiras Pinto | |
| person.familyName | Diogo Gonçalves | |
| person.familyName | Ribeiro | |
| person.familyName | Marques Marto | |
| person.givenName | Pedro Filipe | |
| person.givenName | Lídia Maria | |
| person.givenName | Helena | |
| person.givenName | Joana | |
| person.identifier | 1570599 | |
| person.identifier.ciencia-id | 8D15-FEBC-C15C | |
| person.identifier.ciencia-id | 7211-22BA-86AD | |
| person.identifier.ciencia-id | 161F-B79B-D660 | |
| person.identifier.ciencia-id | 891B-12E1-C2BF | |
| person.identifier.orcid | 0000-0002-5723-0750 | |
| person.identifier.orcid | 0000-0002-6799-2740 | |
| person.identifier.orcid | 0000-0002-2429-7991 | |
| person.identifier.orcid | 0000-0001-5523-5622 | |
| person.identifier.rid | E-2944-2015 | |
| person.identifier.scopus-author-id | 35896704400 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.cv.cienciaid | 7211-22BA-86AD | Lídia Maria Diogo Gonçalves | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
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