Repository logo
 
Publication

Investigations of Olive Oil Industry By-Products Extracts with Potential Skin Benefits in Topical Formulations

2021-03Journal article Open access
Simple item page
dc.contributor.authorNunes, Andreia
dc.contributor.authorGonçalves, Lídia
dc.contributor.authorMarto, Joana
dc.contributor.authorMartins, Ana
dc.contributor.authorSilva, Alexandra N.
dc.contributor.authorPinto, Pedro
dc.contributor.authorMartins, Marta
dc.contributor.authorFraga, Carmo
dc.contributor.authorRibeiro, Helena
dc.date.accessioned2024-01-23T17:12:09Z
dc.date.available2024-01-23T17:12:09Z
dc.date.issued2021-03
dc.date.updated2023-02-27T15:56:13Z
dc.description© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).pt_PT
dc.description.abstractThe by-products of olive oil industry are a major ecological issue due to their phenolic content, highly toxic organic load, and low pH. However, they can be recovered and reused, since their components have antioxidant, anti-inflammatory, and photoprotector properties. In this work, oil-in-water creams containing three different olive oil industry by-products extracts were produced without the use of organic solvents. First, the extracts were thoroughly characterized in vitro for cytotoxicity, inhibition of skin enzymes, and antioxidant and photoprotection capacities. Safety studies were then performed, including ocular and skin irritation tests, ecotoxicity evaluation, and in vivo Human Repeat Insult Patch Test. The results obtained in this initial characterization supported the incorporation of the extracts in the cream formulations. After preparation, the creams were characterized for their organoleptic, physicochemical, droplet size and rheological properties, and microbial contamination. The results showed that all formulations were semi-solid creams, with stable pH, compatible with the skin, without microbial contamination, and with the expected droplet size range. The rheological analysis showed shear-thinning behavior with yield stress, with the viscosity decreasing with increasing shear rate. The oscillatory results suggest that the creams have a strong network structure, being easily rubbed into the skin. Finally, compatibility, acceptability and antioxidant efficacy were evaluated in vivo, in human volunteers. No adverse reactions were observed after application of the formulations on skin and the cream with the highest concentrations of phenolic compounds showed the highest antioxidant efficiency. In conclusion, the results suggest that olive oil industry by-products extracts have valuable properties that favor their re-use in the cosmetic industry. The example presented here showed their successful incorporation into creams and their impact in these formulations’ appearance, pH, and rheological performance, as well as their in vivo compatibility with skin and antioxidant efficiency.pt_PT
dc.description.sponsorshipThis work was supported by Sovena Portugal Consumer Goods through the project Oil4Health: From Olive to Health LISBOA-01-0247-FEDER-038554, funded by the Portugal 2020 program—Programa Operacional Regional de Lisboa. This research was also funded by FCT (Fundação para a Ciência e a Tecnologia) through iMed.ULisboa UID/DTP/04138/2019 and UIDB/04138/2020), principal investigator grants CEECIND/03143/2017 (L. M. Gonçalves). Joana Marto is financed through FCT, I.P., under the Scientific Employment Stimulus—Institutional Call (CEECINST/00145/2018). Marta Martins is financed through FCT, I.P., under the Scientific Employment Stimulus—Institutional Call (CEECINST/00102/2018). The work was supported by the Marine and Environmental Sciences Centre—MARE (UIDB04292/2020; UIDP/04292/2020).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNunes A, Gonçalves L, Marto J, Martins AM, Silva AN, Pinto P, et al. Investigations of olive oil industry by-products extracts with potential skin benefits in topical formulations. Pharmaceutics [Internet]. abril de 2021;13(4):465. Disponível em: https://www.mdpi.com/1999-4923/13/4/465pt_PT
dc.identifier.doi10.3390/pharmaceutics13040465pt_PT
dc.identifier.issn1999-4923
dc.identifier.slugcv-prod-2779248
dc.identifier.urihttp://hdl.handle.net/10451/62050
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationCEECINST/00102/2018pt_PT
dc.relationResearch Institute for Medicines
dc.relationResearch Institute for Medicines
dc.relationNot Available
dc.relationNot Available
dc.relationNot Available
dc.relationNot Available
dc.relationMarine and Environmental Sciences Centre
dc.relationMarine and Environmental Sciences Centre
dc.relation.publisherversionhttps://www.mdpi.com/1999-4923/13/4/465pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectolive oil industry by-productspt_PT
dc.subjectextractspt_PT
dc.subjectcreamspt_PT
dc.subjectcytotoxicitypt_PT
dc.subjectecotoxicitypt_PT
dc.subjectantioxidantpt_PT
dc.titleInvestigations of Olive Oil Industry By-Products Extracts with Potential Skin Benefits in Topical Formulationspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleResearch Institute for Medicines
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleNot Available
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FDTP%2F04138%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04138%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F03143%2F2017%2FCP1476%2FCT0005/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0001/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0002/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00145%2F2018%2FCP1571%2FCT0003/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04292%2F2020/PT
oaire.citation.issue4pt_PT
oaire.citation.startPage465pt_PT
oaire.citation.titlePharmaceuticspt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2017
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
oaire.fundingStreamCEEC INST 2018
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGermano Nunes
person.familyNameDiogo Gonçalves
person.familyNameMarques Marto
person.familyNameMartins
person.familyNameCapêlo Contreiras Pinto
person.familyNameMartins
person.familyNameRibeiro
person.givenNameAndreia Alexandra
person.givenNameLídia Maria
person.givenNameJoana
person.givenNameAna
person.givenNamePedro Filipe
person.givenNameMarta
person.givenNameHelena
person.identifier129361
person.identifier1570599
person.identifier.ciencia-id341E-127F-B86D
person.identifier.ciencia-id7211-22BA-86AD
person.identifier.ciencia-id891B-12E1-C2BF
person.identifier.ciencia-id8D15-FEBC-C15C
person.identifier.ciencia-id7810-1C0F-20D4
person.identifier.ciencia-id161F-B79B-D660
person.identifier.orcid0000-0002-6133-9943
person.identifier.orcid0000-0002-6799-2740
person.identifier.orcid0000-0001-5523-5622
person.identifier.orcid0000-0003-4822-3249
person.identifier.orcid0000-0002-5723-0750
person.identifier.orcid0000-0002-3818-6256
person.identifier.orcid0000-0002-2429-7991
person.identifier.ridE-2944-2015
person.identifier.scopus-author-id35603849900
person.identifier.scopus-author-id35896704400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid7211-22BA-86AD | Lídia Maria Diogo Gonçalves
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicatione399fb6d-5fdc-46a6-9a0d-ea2e16ea8c8a
relation.isAuthorOfPublication3265148d-dc2d-4601-a832-2e72f7be5662
relation.isAuthorOfPublication07221f19-3d9a-4bd5-88c4-1e066b49856f
relation.isAuthorOfPublicationad5d82f4-e97a-4a61-8091-d8d8c837c11d
relation.isAuthorOfPublication9f0f85fd-1ea5-45f7-901a-b7342c09fedc
relation.isAuthorOfPublication1edab515-0acc-4dc8-b94e-eb44cad2538c
relation.isAuthorOfPublication4d78eb31-9c99-4533-90cc-972b150498a2
relation.isAuthorOfPublication.latestForDiscoverye399fb6d-5fdc-46a6-9a0d-ea2e16ea8c8a
relation.isProjectOfPublicationf7ed2a0a-c67e-4c12-ad63-b550724e24bf
relation.isProjectOfPublicationbb00962c-ed82-4d7a-bc37-61df49767d93
relation.isProjectOfPublication1b37be44-5343-44b3-a5b0-3805bd6ad22b
relation.isProjectOfPublication8c0687fc-3c83-47d4-b3c8-d7969049710e
relation.isProjectOfPublication2ec338a7-25b0-474e-9d29-0d6046e3310d
relation.isProjectOfPublication71788a88-fa25-4ca1-8a28-19755c9bb40e
relation.isProjectOfPublication4ef28e92-cf9f-41e8-b87f-2ad3b85428c4
relation.isProjectOfPublication8a65aec7-285b-4c42-99cc-5870b8faf640
relation.isProjectOfPublication.latestForDiscovery4ef28e92-cf9f-41e8-b87f-2ad3b85428c4

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Nunes_et_al_2021.pdf
Size:
3.94 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

FF - CiênciaVitae - Faculdade de Farmácia