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Designing improved active peptides for therapeutic approaches against infectious diseases

2018Journal article Restricted access
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dc.contributor.authorGomes, Bárbara
dc.contributor.authorAugusto, Marcelo T.
dc.contributor.authorFelício, Mário Romão
dc.contributor.authorHollmann, Axel
dc.contributor.authorFranco, Octávio L.
dc.contributor.authorAbreu, Sónia Gonçalves
dc.contributor.authorSantos, Nuno C.
dc.date.accessioned2019-03-25T12:16:45Z
dc.date.available2019-03-25T12:16:45Z
dc.date.issued2018
dc.description© 2018 Elsevier Inc. All rights reserved.pt_PT
dc.description.abstractInfectious diseases are one of the main causes of human morbidity and mortality. In the last few decades, pathogenic microorganisms' resistance to conventional drugs has been increasing, and it is now pinpointed as a major worldwide health concern. The need to search for new therapeutic options, as well as improved treatment outcomes, has therefore increased significantly, with biologically active peptides representing a new alternative. A substantial research effort is being dedicated towards their development, especially due to improved biocompatibility and target selectivity. However, the inherent limitations of peptide drugs are restricting their application. In this review, we summarize the current status of peptide drug development, focusing on antiviral and antimicrobial peptide activities, highlighting the design improvements needed, and those already being used, to overcome the drawbacks of the therapeutic application of biologically active peptides.pt_PT
dc.description.sponsorshipThis work was supported by Fundação para a Ciência e a Tecnologia – Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) project PTDC/BBB-BQB/3494/2014, by Marie SkłodowskaCurie Research and Innovation Staff Exchange (MSCA-RISE, European Union) project INPACT (call H2020-MSCA-RISE-2014, grant agreement 644167), by the Brazilian funding agencies Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo a Pesquisa do Distrito Federal (FAPDF) and by Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT). BG, MA and MF acknowledge FCT-MCTES fellowships SPRH/BD/ 52431/2013, SPRH/BD/95624/2013 and SPRH/BD/100517/2014, respectively.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationBiotechnology Advances 36 (2018) 415–429pt_PT
dc.identifier.doi10.1016/j.biotechadv.2018.01.004pt_PT
dc.identifier.issn0734-9750
dc.identifier.urihttp://hdl.handle.net/10451/37677
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationSPRH/BD/ 52431/2013pt_PT
dc.relationSPRH/BD/95624/2013pt_PT
dc.relationSPRH/BD/100517/2014pt_PT
dc.relationBroad-spectrum antiviral peptides against respiratory viruses
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/biotechnology-advancespt_PT
dc.subjectBiologically active peptidespt_PT
dc.subjectAntimicrobial peptidespt_PT
dc.subjectAntiviral peptidespt_PT
dc.subjectCell-penetrating peptidespt_PT
dc.subjectPeptide-based drugspt_PT
dc.titleDesigning improved active peptides for therapeutic approaches against infectious diseasespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBroad-spectrum antiviral peptides against respiratory viruses
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBBB-BQB%2F3494%2F2014/PT
oaire.citation.endPage429pt_PT
oaire.citation.startPage415pt_PT
oaire.citation.titleBiotechnology Advancespt_PT
oaire.citation.volume36pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameAugusto
person.familyNameRomão Felício
person.familyNameHollmann
person.familyNameAbreu
person.familyNameSantos
person.givenNameMarcelo
person.givenNameMário
person.givenNameAxel
person.givenNameSónia
person.givenNameNuno
person.identifier384205
person.identifier198825
person.identifier.ciencia-id9E16-D9F8-1807
person.identifier.ciencia-idF811-74AE-412A
person.identifier.ciencia-idCD13-5E3A-A3C5
person.identifier.orcid0000-0002-6536-3924
person.identifier.orcid0000-0002-9398-2140
person.identifier.orcid0000-0002-8060-2997
person.identifier.orcid0000-0003-2903-4282
person.identifier.orcid0000-0002-0580-0475
person.identifier.ridJ-8517-2014
person.identifier.ridH-9482-2017
person.identifier.ridN-7248-2013
person.identifier.scopus-author-id57144367400
person.identifier.scopus-author-id15848341400
person.identifier.scopus-author-id35602210000
person.identifier.scopus-author-id55940818300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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