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Identification of erythrocyte biomarkers in amyotrophic lateral sclerosis

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dc.contributor.authorLima, Catarina
dc.contributor.authorPinto, Susana
dc.contributor.authorNapoleão, Patricia
dc.contributor.authorLaborinho, Ana Catarina Pronto
dc.contributor.authorBarros, Maria Amparo
dc.contributor.authorFreitas, Teresa
dc.contributor.authorCarvalho, Mamede
dc.contributor.authorSaldanha, Carlota
dc.date.accessioned2018-07-17T10:48:55Z
dc.date.available2018-07-17T10:48:55Z
dc.date.issued2016
dc.description© IOS Press and the authors. All rights reservedpt_PT
dc.description.abstractINTRODUCTION: Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease of the motor system. It has been hypothesised that red blood cells (RBCs) may be involved in the disease process by the release of damaging molecules. OBJECTIVE: The aim of this ex vivo study is to compare RBCs biochemical and hemorheological parameters between ALS patients and healthy donors to identify novel biomarkers of the ALS disease. METHODS: We included 82 ALS patients and 40 gender age-matched healthy donors. We performed quantification of erythrocyte aggregation and deformability, nitric oxide (NO) efflux from RBCs, acetylcholinesterase (AChE) enzyme activity and intraerythrocytic concentration of nitrite, nitrate and S-nitrosogluthatione (GSNO). RESULTS: Erythrocyte deformability and AChE activity were increased in patients with ALS in comparison to healthy donors. NO efflux from RBCs and concentration of intraerythrocytic nitrite were lower in ALS patients. In patients, we found that for higher NO range of values the respiratory function is worse and that for higher AChE range of values the RBCs nitrite content increase. CONCLUSION: The results of the present study indicate that NO efflux from RBCs and RBCs AChE should be further explored as potential biomarkers for ALS.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClinical Hemorheology and Microcirculation 63 (2016) 423–437pt_PT
dc.identifier.doi10.3233/CH-162066pt_PT
dc.identifier.issn1386-0291
dc.identifier.urihttp://hdl.handle.net/10451/34182
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherIOS Presspt_PT
dc.relation.publisherversionhttps://www.iospress.nl/journal/clinical-hemorheology-and-microcirculation/pt_PT
dc.subjectAcetylcholinesterasept_PT
dc.subjectAmyotrophic lateral sclerosispt_PT
dc.subjectErythrocytept_PT
dc.subjectNitric oxidept_PT
dc.subjectNitritept_PT
dc.subjectRespiratory functionpt_PT
dc.titleIdentification of erythrocyte biomarkers in amyotrophic lateral sclerosispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage437pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage423pt_PT
oaire.citation.titleClinical Hemorheology and Microcirculationpt_PT
oaire.citation.volume63pt_PT
person.familyNamePinto
person.familyNameNapoleão
person.familyNamede Carvalho
person.familyNameSaldanha
person.givenNameSusana
person.givenNamePatrícia
person.givenNameMamede
person.givenNameCarlota
person.identifier593760
person.identifier53901
person.identifier.ciencia-idD31B-E89C-CB94
person.identifier.ciencia-idC11E-8BE9-A97F
person.identifier.orcid0000-0002-0727-5897
person.identifier.orcid0000-0002-5896-1440
person.identifier.orcid0000-0001-7556-0158
person.identifier.orcid0000-0002-5058-2112
person.identifier.ridL-8394-2019
person.identifier.scopus-author-id23397978500
person.identifier.scopus-author-id8872775500
person.identifier.scopus-author-id7101893769
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication3fa09e71-c9b7-4536-a359-f7e3576dca09
relation.isAuthorOfPublicationc74643c7-434c-4310-9b98-2fcaa9fdd4b3
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relation.isAuthorOfPublicationad6de30c-87ca-4613-bb87-488dd5d285d0
relation.isAuthorOfPublication.latestForDiscoveryc74643c7-434c-4310-9b98-2fcaa9fdd4b3

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