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Nutritional risks and colorectal cancer in a Portuguese population

2005Journal article Open access
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dc.contributor.authorRavasco, Paula
dc.contributor.authorMonteiro Grillo, isabel
dc.contributor.authorMarques-Vidal, Pedro
dc.contributor.authorCamilo, Maria
dc.date.accessioned2021-05-05T14:43:05Z
dc.date.available2021-05-05T14:43:05Z
dc.date.issued2005
dc.descriptionLicencia creative commons: Open Access bajo la licencia Creative Commons 4.4 CC BY-NC-SApt_PT
dc.description.abstractBackground: Food and nutrition as major causes of colorectal cancer (CRC) are still debatable. Aim of the study: This cross-sectional study in a Portuguese population aimed to characterize and identify "high-risk" diets/life-styles and explore their associations with colorectal cancer. Methods: In 70 colorectal cancer patients and 70 sex, age-matched subjects without cancer history, we evaluated: diet history and detailed nutrient intake (DIET-PLAN5 2002, UK), alcohol (amount, type, years), smoking (number packages/year, years), physical activity, co-morbidities and body mass index. Age-adjusted Relative Risks were calculated, Proportional Hazards models adjusted the analysis for multiple risk factors. Results: Smoking was a risk factor (1.90). Increased colorectal cancer risk regarding the lowest vs the highest intake quartile emerged for: vitamin B12 (3.41), cholesterol (3.15), total fat (2.87), saturated fat (1.98), animal protein (1.95), energy (1.85), alcohol (1.70), iron (1.49), refined carbohydrates (1.39). Reduced colorectal cancer risk for the highest vs the lowest intake quartile was found for: n-3 fatty acids (0.10), insoluble fiber/folate (0.15), flavonoids/vitamin E (0.25), isoflavones/beta-carotene (0.30), selenium (0.36), copper (0.41), vitamin B6 (0.46). Conclusion: Our results corroborated well-established risk factors and identified emergent nutrients. Prolonged excessive intake of macronutrients and some micronutrients concurrent with marked deficits of fiber and protective compounds were dominant in colorectal cancer and more significant than alcohol and smoking. The interaction diet-colorectal cancer is consistent and the relevance of new nutrients is emerging.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNutr Hosp. 2005 May-Jun;20(3):165-172pt_PT
dc.identifier.issn0212-1611
dc.identifier.urihttp://hdl.handle.net/10451/47663
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherArán Edicionespt_PT
dc.relation.publisherversionhttps://www.nutricionhospitalaria.org/pt_PT
dc.relation.publisherversionhttps://scielo.isciii.es/scielo.php?script=sci_issues&pid=0212-1611&lng=en&nrm=iso/content/by/year/2013pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectColorectal cancerpt_PT
dc.subjectRisk factorspt_PT
dc.subjectDietpt_PT
dc.subjectNutrientspt_PT
dc.subjectAlcoholpt_PT
dc.subjectTobaccopt_PT
dc.titleNutritional risks and colorectal cancer in a Portuguese populationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage172pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage165pt_PT
oaire.citation.titleNutricion Hospitalariapt_PT
oaire.citation.volume20pt_PT
person.familyNameRavasco
person.familyNamemonteiro grillo
person.familyNameMarques-Vidal
person.givenNamePaula
person.givenNameisabel
person.givenNamePedro
person.identifier381093
person.identifier.ciencia-id2E1E-155A-9B23
person.identifier.orcid0000-0002-6056-8269
person.identifier.orcid0000-0002-2481-5576
person.identifier.orcid0000-0002-4548-8500
person.identifier.ridC-9449-2009
person.identifier.scopus-author-id6602551513
person.identifier.scopus-author-id55651163200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationc44c651e-a6a4-4755-a6b6-2431eef3ea93
relation.isAuthorOfPublication2c5b91e4-fc73-4396-b483-95dc9e893633
relation.isAuthorOfPublicationd49496b1-af7a-430c-b616-0e52f9173e7c
relation.isAuthorOfPublication.latestForDiscoveryc44c651e-a6a4-4755-a6b6-2431eef3ea93

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