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Cognitive dysfunction during migraine attacks: a study on migraine without aura

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dc.contributor.authorGil-Gouveia, Raquel
dc.contributor.authorOliveira, António G.
dc.contributor.authorMartins, Isabel Pavão
dc.date.accessioned2022-06-14T15:58:12Z
dc.date.available2022-06-14T15:58:12Z
dc.date.issued2014
dc.description© International Headache Society 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.navpt_PT
dc.description.abstractBackground: Cognitive difficulties contribute to patients' disability during migraine attacks and have been overlooked in migraine research. Neuropsychological studies performed during attacks have produced inconsistent findings due to design differences and limitations. Objective: Our objective is to document changes in cognitive performance of migraine patients during migraine attacks with a comprehensive battery of cognitive/behavioral tests, while controlling for potential confounders. Method: A prospective two-period, randomized, cross-over study compared within-subject neuropsychological evaluation in two conditions-during a naturally occurring untreated migraine attack and a headache-free period. Results: Thirty-nine patients with episodic migraine (37 females, average 38 years old) were included and 24 completed the study. Participants performed worse during the attack in the majority of cognitive tests, compared to the headache-free status, and significantly so in word reading speed (p = 0.013), verbal learning (p = 0.01), short-term verbal recall with (p = 0.01) and without (p = 0.013) semantic cueing and delayed recall with (p = 0.003) and without (p = 0.05) semantic cues. Differences found were unrelated to age, gender, literacy, condition order, interval between evaluations, anxiety, pain intensity or duration of the attack. Discussion: Cognitive performance decreases during migraine attacks, especially in reading and processing speed, verbal memory and learning, supporting patients' subjective complaints. These findings suggest the existence of a reversible brain dysfunction during attacks of migraine without aura, which can relate specifically to migraine or be a consequence of acute pain processing by the brain.pt_PT
dc.description.sponsorshipThis work was supported by the Portuguese Headache Society-Tecnifar investigation grant.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCephalalgia . 2015 Jul;35(8):662-674pt_PT
dc.identifier.doi10.1177/0333102414553823pt_PT
dc.identifier.eissn1468-2982
dc.identifier.issn0333-1024
dc.identifier.urihttp://hdl.handle.net/10451/53382
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSAGE Journalspt_PT
dc.relation.publisherversionhttps://journals.sagepub.com/home/ceppt_PT
dc.subjectMigrainept_PT
dc.subjectCognitive symptomspt_PT
dc.subjectDisease burdenpt_PT
dc.subjectExecutive dysfunctionpt_PT
dc.titleCognitive dysfunction during migraine attacks: a study on migraine without aurapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage674pt_PT
oaire.citation.issue8pt_PT
oaire.citation.startPage662pt_PT
oaire.citation.titleCephalalgiapt_PT
oaire.citation.volume35pt_PT
person.familyNameGil-Gouveia
person.familyNamePavão Martins
person.givenNameRaquel
person.givenNameIsabel
person.identifier389864
person.identifier18561
person.identifier.ciencia-id6D18-4F7A-E69D
person.identifier.ciencia-id4D1D-4040-BE76
person.identifier.orcid0000-0002-4256-4256
person.identifier.orcid0000-0002-9611-7400
person.identifier.scopus-author-id7103152782
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4d5a66aa-00f8-44ac-998c-728c2583b927
relation.isAuthorOfPublicationd134f8f9-be2a-4990-b8ec-3159ff3c51f2
relation.isAuthorOfPublication.latestForDiscovery4d5a66aa-00f8-44ac-998c-728c2583b927

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