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Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma

2021-01-01Journal article Open access
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dc.contributor.authorNascimento, Catarina
dc.contributor.authorGameiro, Andreia
dc.contributor.authorFerreira, Fernando
dc.contributor.authorCorreia, Jorge Manuel de Jesus
dc.contributor.authorFerreira, João
dc.date.accessioned2022-02-13T22:57:13Z
dc.date.available2022-02-13T22:57:13Z
dc.date.issued2021-01-01
dc.descriptionResearch Areas: Oncologypt_PT
dc.description.abstractVascular endothelial growth factor (VEGF-A) plays an essential role in tumor-associated angiogenesis, exerting its biological activity by binding and activating membrane receptors, as vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2). In this study, serum VEGF-A, VEGFR1, and VEGFR-2 levels were quantified in 50 cats with mammary carcinoma and 14 healthy controls. The expression of these molecules in tumor-infiltrating lymphocytes (TILs) and in cancer cells was evaluated and compared with its serum levels. Results obtained showed that serum VEGF-A levels were significantly higher in cats with HER2-positive and Triple Negative (TN) Normal-Like subtypes, when compared to control group (p = 0.001, p = 0.020). Additionally, serum VEGFR-1 levels were significantly elevated in cats presenting luminal A, HER2-positive and TN Normal-Like tumors (p = 0.011, p = 0.048, p = 0.006), as serum VEGFR-2 levels (p = 0.010, p = 0.046, p = 0.005). Moreover, a positive interaction was found between the expression of VEGF-A, VEGFR-1, and VEGFR-2 in TILs and their serum levels (p = 0.002, p = 0.003, p = 0.003). In summary, these findings point to the usefulness of VEGF-A and its serum receptors assessment in clinical evaluation of cats with HER2-positive and TN Normal-Like tumors, suggesting that targeted therapies against these molecules may be effective for the treatment of these animals, as described in human breast cancer.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNascimento C, Gameiro A, Ferreira J, Correia J, Ferreira F. 2021. Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma. Cancers, 13(1):117. Doi: 10.3390/cancers13010117pt_PT
dc.identifier.doi10.3390/cancers13010117pt_PT
dc.identifier.eissn2072-6694
dc.identifier.urihttp://hdl.handle.net/10400.5/23477
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationC00191rpt_PT
dc.relationCentre for Interdisciplinary Research in Animal Health
dc.relationDeveloping diagnostic tools for feline mammary carcinomas and improving chemotherapy based on HER2 and topoisometase status
dc.relation.publisherversionhttps://www.mdpi.com/2072-6694/13/1/117pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectFeline mammary carcinomapt_PT
dc.subjectVEGF-Apt_PT
dc.subjectVEGFR-1pt_PT
dc.subjectVEGFR-2pt_PT
dc.subjectNon-invasive biomarkerspt_PT
dc.subjectAngiogenesispt_PT
dc.titleDiagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinomapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Interdisciplinary Research in Animal Health
oaire.awardTitleDeveloping diagnostic tools for feline mammary carcinomas and improving chemotherapy based on HER2 and topoisometase status
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FCVT-EPI%2F3638%2F2014/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00276%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F132260%2F2017/PT
oaire.citation.conferencePlaceBasel, Switzerlandpt_PT
oaire.citation.titleCancerspt_PT
oaire.citation.volumeVol. 13(1):117pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
person.familyNameGaspar do Nascimento
person.familyNameGameiro
person.familyNameFerreira
person.familyNameJesus Correia
person.givenNameAna Catarina
person.givenNameAndreia
person.givenNameFernando António da Costa
person.givenNameJorge Manuel
person.identifier.ciencia-idB718-5199-AA36
person.identifier.ciencia-idF81F-D7D4-57C5
person.identifier.ciencia-id7311-54F2-A545
person.identifier.orcid0000-0002-1602-3552
person.identifier.orcid0000-0001-5765-576X
person.identifier.orcid0000-0002-1909-4540
person.identifier.scopus-author-id7202364133
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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