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Markers for upper limb dysfunction in Amyotrophic Lateral Sclerosis using analysis of typing activity

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dc.contributor.authorLondral, Ana
dc.contributor.authorPinto, Susana
dc.contributor.authorCarvalho, Mamede
dc.date.accessioned2022-06-21T13:45:02Z
dc.date.available2022-06-21T13:45:02Z
dc.date.issued2016
dc.description© 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.pt_PT
dc.description.abstractObjective: Assistive devices based on keyboard access support communication and control tools for patients with Amyotrophic Lateral Sclerosis (ALS). The aim of this work was to explore movement activity in the use of keyboards and identify markers for upper limb (UL) dysfunction. Methods: We present a longitudinal study including 19 ALS patients, followed for 2-20 months. Typing activity was recorded with an accelerometer placed on the posterior part of patients' index finger. Participants performed the same 10-word typing task (2-6 assessments). Time and acceleration during keystroke were the main outcomes of this study. Patients were compared with 20 healthy subjects and 6 patients with other neuromuscular disorders. Results: During disease progression, mean time in holding down a key increased and was longer than in control subjects. Acceleration at key press and key release decreased with progression of UL dysfunction. Delay between tapping and pressing down each key increased with UL dysfunction. Conclusions: Delay in pressing and releasing keys are markers of UL dysfunction in ALS. The decrease in the acceleration of movements related to keystroke can contribute to monitor disease progression. Significance: Typing activity can be explored to access remotely and continuously to ALS progression by patients who use assistive communication devices.pt_PT
dc.description.sponsorshipThis work was partially supported by Calouste Gulbenkian Foundation and the National ALS Association (APELA).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Neurophysiol. 2016 Jan;127(1):925-931pt_PT
dc.identifier.doi10.1016/j.clinph.2015.06.017pt_PT
dc.identifier.eissn1872-8952
dc.identifier.issn1388-2457
dc.identifier.urihttp://hdl.handle.net/10451/53419
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/clinical-neurophysiologypt_PT
dc.subjectAmyotrophic Lateral Sclerosispt_PT
dc.subjectAssistive devicespt_PT
dc.subjectFunctional assessmentpt_PT
dc.subjectHome monitoringpt_PT
dc.subjectUpper limbs dysfunctionpt_PT
dc.titleMarkers for upper limb dysfunction in Amyotrophic Lateral Sclerosis using analysis of typing activitypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage931pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage925pt_PT
oaire.citation.titleClinical Neurophysiologypt_PT
oaire.citation.volume127pt_PT
person.familyNameLondral
person.familyNamePinto
person.familyNamede Carvalho
person.givenNameAna Rita
person.givenNameSusana
person.givenNameMamede
person.identifier593760
person.identifier.ciencia-id3113-84DE-0C47
person.identifier.ciencia-idD31B-E89C-CB94
person.identifier.orcid0000-0002-8002-6790
person.identifier.orcid0000-0002-0727-5897
person.identifier.orcid0000-0001-7556-0158
person.identifier.ridL-8394-2019
person.identifier.scopus-author-id23397978500
person.identifier.scopus-author-id7101893769
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb2f31b62-1f8b-445d-837b-b7dc92f58c89
relation.isAuthorOfPublication3fa09e71-c9b7-4536-a359-f7e3576dca09
relation.isAuthorOfPublicationdd7f55d4-c2b5-4fd2-9bd1-a9542a62f58f
relation.isAuthorOfPublication.latestForDiscovery3fa09e71-c9b7-4536-a359-f7e3576dca09

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