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Association of gastric lymphofollicular hyperplasia with Helicobacter-like organisms in dogs
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Resumo(s)
ABSTRACT - Background: The relationships among gastric lymphoid follicular hyperplasia (GLFH),
Helicobacter-like organisms (HLOs), and clinical signs have not been established
in dogs.
Objectives: To evaluate the epidemiologic, clinical, endoscopic, and histopathologic
findings associated with GLFH in dogs, and determine the association of GLFH with
HLOs and the French Bulldog (FB) breed.
Animals: Two hundred eighty-eight dogs that underwent gastroscopy between 2013
and 2016.
Methods: Retrospective, cross-sectional study. Gastric biopsy samples were
reviewed and scored for inflammation and HLOs. Dogs were divided into 3 groups:
group 1 (63 FBs), group 2 (45 non-FB brachycephalic dogs), and group
3 (180 nonbrachycephalic dogs). Variables were evaluated for their association
with GLFH.
Results: Univariate analysis determined that intact males, young age, vomiting, gastroscopic findings (discoloration, hemorrhage, and ulcers), and histopathologic findings (gastric lamina propria lymphocytic infiltration and HLO score) were associated
with GLFH (P ≤ .03). In the multivariate analysis, GLFH was associated with the HLO
score (odds ratio [OR] > 5 for HLO scores 1-2 and >15 for HLO score of 3; P < .001),
with vomiting (OR > 4; P = .01) but not with FB breed (P = .76) and age (P = .1). The
HLO score was associated with younger age (P < .001).
Conclusion and Clinical Importance: The HLO score was associated with a high
GLFH score. Vomiting was associated with GLFH. Helicobacter-like organisms are
highly prevalent in young dogs and GLFH is indirectly associated with this factor.
Clinical relevance of the identification of GLFH and HLO remains to be determined.
Descrição
Research Areas: Veterinary Sciences
Palavras-chave
Bacterial Bacterial species Chronic gastritis Dog Gastric follicular hyperplasia Gastroenterology Helicobactermicrobiology
Contexto Educativo
Citação
Bienes T, Leal RO, Dominguez-Ruiz M, De Carvalho RE, Rodrigues NF, Dally C, Husson JC, Le Boedec K, Hernandes Juan. 2022. Journal of Veterinary Internal Medicine, 36(2):p.515-524. DOI: 10.1111/jvim.16387
Editora
Wiley