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New frontiers for anti-biofilm drug development

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dc.contributor.authorRibeiro, Suzana M.
dc.contributor.authorFelício, Mário Romão
dc.contributor.authorBoas, Esther Vilas
dc.contributor.authorAbreu, Sónia Gonçalves
dc.contributor.authorCosta, Fabrício F.
dc.contributor.authorSamy, Ramar Perumal
dc.contributor.authorSantos, Nuno
dc.contributor.authorFranco, Octávio L.
dc.date.accessioned2019-03-25T11:38:39Z
dc.date.available2019-03-25T11:38:39Z
dc.date.issued2016
dc.description© 2016 Elsevier Inc. All rights reservedpt_PT
dc.description.abstractPathogenic microbial biofilm, a consortium of microbial cells protected by a self-produced polymer matrix, is considered a worldwide challenge due to the inherent antibiotic resistance conferred by its lifestyle. Living, as it does, in a community of microbial organisms in a clinical situation, makes it responsible for severe and dangerous cases of infection. Combating this organisation of cells usually requires high antibiotic doses for a prolonged time, and these approaches often fail, contributing to infection persistence. In addition to therapeutic limitations, biofilms can be a source of infections when they grow inmedical devices. The challenge imposed by biofilms has mobilised researchers in the entire world to prospect or develop alternatives to control biofilms. In this context, this review summarises the new frontiers that could be used in clinical circumstances in order to prevent or eliminate pathogenic biofilms.pt_PT
dc.description.sponsorshipThis work was supported by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil), Conselho Nacional de Pesquisa e Desenvolvimento (CNPq, Brazil), Fundação de Amparo à Pesquisa do Distrito Federal (FAPDF, Brazil), Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul (FUNDECT, Brazil), Fundação para a Ciência e a Tecnologia –Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal), including the fellowcship SPRH/BD/ 100517/2014 to M.R.F., and Marie Skłodowska-Curie Research and Innovation Staff Exchange (MSCA-RISE, European Union) project INPACT (call H2020-MSCA-RISE-2014, grant agreement 644167).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPharmacology & Therapeutics 160 (2016) 133–144pt_PT
dc.identifier.doi10.1016/j.pharmthera.2016.02.006pt_PT
dc.identifier.issn0163-7258
dc.identifier.urihttp://hdl.handle.net/10451/37673
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationSPRH/BD/100517/2014pt_PT
dc.relation644167pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/pharmacology-and-therapeuticspt_PT
dc.subjectAnti-biofilm peptidespt_PT
dc.subjectBiofilmspt_PT
dc.subjectDrug repurposingpt_PT
dc.subjectNanotechnologypt_PT
dc.subjectPolymicrobial biofilmpt_PT
dc.titleNew frontiers for anti-biofilm drug developmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage144pt_PT
oaire.citation.startPage133pt_PT
oaire.citation.titlePharmacology & Therapeuticspt_PT
oaire.citation.volume160pt_PT
person.familyNameRomão Felício
person.familyNameAbreu
person.familyNameSantos
person.givenNameMário
person.givenNameSónia
person.givenNameNuno
person.identifier384205
person.identifier.ciencia-idF811-74AE-412A
person.identifier.ciencia-idCD13-5E3A-A3C5
person.identifier.orcid0000-0002-9398-2140
person.identifier.orcid0000-0003-2903-4282
person.identifier.orcid0000-0002-0580-0475
person.identifier.ridJ-8517-2014
person.identifier.ridH-9482-2017
person.identifier.ridN-7248-2013
person.identifier.scopus-author-id57144367400
person.identifier.scopus-author-id35602210000
person.identifier.scopus-author-id55940818300
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication8d7bbafe-ae5e-418e-8224-6af22991a3e7
relation.isAuthorOfPublicationc077a1e4-3d11-47c7-b5d4-29a5a4190a35
relation.isAuthorOfPublication4656d912-5a2d-4c80-8921-2bcba3aa441a
relation.isAuthorOfPublication.latestForDiscovery8d7bbafe-ae5e-418e-8224-6af22991a3e7

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