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Factors associated with health‐related quality of life in late‐stage Parkinson's disease

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dc.contributor.authorRosqvist, Kristina
dc.contributor.authorOdin, Per
dc.contributor.authorLorenzl, Stefan
dc.contributor.authorMeissner, Wassilios G.
dc.contributor.authorBloem, Bastiaan R.
dc.contributor.authorFerreira, Joaquim J
dc.contributor.authorDodel, Richard
dc.contributor.authorSchrag, Anette
dc.date.accessioned2021-10-18T13:34:15Z
dc.date.available2021-10-18T13:34:15Z
dc.date.issued2021
dc.description© 2021 The Authors. Movement Disorders Clinical Practice published by Wiley Periodicals LLC on behalf of Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.pt_PT
dc.description.abstractBackground: There is limited knowledge on health-related quality of life (HRQoL) in late-stage Parkinson's disease (PD). Objective: To assess factors associated with HRQoL in patients with late-stage PD, with a focus on health care provision. Methods: The Care of Late Stage Parkinsonism (CLaSP) project is the largest study on late-stage PD to date. The current study analyzed data of 401 patients from 6 European countries in whom HRQoL was assessed with the 8-item PD Questionnaire in patients without dementia. Factors potentially associated with HRQoL were assessed and examined in linear regression analyses. Results: Better HRQoL was associated with living at home, greater independence in activities of daily living (Schwab and England Scale), less severe disease (Hoehn and Yahr stage), better motor function (Unified PD Rating Scale Part III), and lower non-motor symptoms burden (Non-Motor Symptoms Scale [NMSS]) across all NMSS domains. Having a PDspecialist as physician for PD, contact with a PDnurse, and no hospital admission during the past 3 months were associated with better HRQoL, but having seen a physiotherapist or occupational therapist was associated with worse HRQoL. Conclusions: The results emphasize the importance of optimizing treatment for motor and multiple non-motor symptoms to improve HRQoL in patients with late-stage PD. PD-specific health care resources, particularly PDnurses, are likely important in addressing issues to improve HRQoL in this population. Worse HRQoL in those who had recently seen a physiotherapist or occupational therapist may reflect referral based on factors not measured in this study.pt_PT
dc.description.sponsorshipThe study was funded through the Joint Programme–Neurodegenerative Disease Research; through national funding bodies in all 6 countries—United Kingdom: Economic and Social Research Council ES/L009250/1; Sweden: the Swedish Research Council and CLaSP/JPND HC-559-002; Germany: Federal Ministry of Education and Research (BMBF), Marburg, 01ED1403A, Munich, 01ED1403B; France: ANR-13-JPHC-0001-07; Portugal: HC/0002/2012; Holland: 733051003. In addition, the study was funded by MultiPark, the strategic research area for neuroscience at Lund University; the Swedish Parkinson Foundation; the Swedish Parkinson Academy, and the Faculty of Medicine at Lund University.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMov Disord Clin Pract. 2021 Mar 23;8(4):563-570pt_PT
dc.identifier.doi10.1002/mdc3.13186pt_PT
dc.identifier.eissn2330-1619
dc.identifier.urihttp://hdl.handle.net/10451/49929
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sons, Inc.pt_PT
dc.relationCare for Late Stage Parkinsonism
dc.relation.publisherversionhttps://movementdisorders.onlinelibrary.wiley.com/journal/23301619pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectParkinsonʼs diseasept_PT
dc.subjectHealth carept_PT
dc.subjectHealth‐related quality of lifept_PT
dc.subjectLatestagept_PT
dc.titleFactors associated with health‐related quality of life in late‐stage Parkinson's diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberJPND-HC/0002/2012
oaire.awardTitleCare for Late Stage Parkinsonism
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/JPND-HC%2F0002%2F2012/PT
oaire.citation.endPage570pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage563pt_PT
oaire.citation.titleMovement Disorders Clinical Practicept_PT
oaire.citation.volume8pt_PT
oaire.fundingStream3599-PPCDT
person.familyNameFerreira
person.givenNameJoaquim J
person.identifier1624753
person.identifier.ciencia-id7D15-5CD6-6159
person.identifier.orcid0000-0003-3950-5113
person.identifier.scopus-author-id7403252466
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication54d84fe7-2cbd-4ddc-bce2-0ff2bd7c4cc9
relation.isAuthorOfPublication.latestForDiscovery54d84fe7-2cbd-4ddc-bce2-0ff2bd7c4cc9
relation.isProjectOfPublication8e1e953f-7d9c-4d6a-9dcb-2e63ba544f15
relation.isProjectOfPublication.latestForDiscovery8e1e953f-7d9c-4d6a-9dcb-2e63ba544f15

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