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Uncomplicated intraventricular hemorrhage is not associated with lower estimated cerebral volume at term age

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dc.contributor.authorGraca, Andre M.
dc.contributor.authorCowan, Frances M.
dc.date.accessioned2021-02-02T13:12:14Z
dc.date.available2021-02-02T13:12:14Z
dc.date.issued2021
dc.description© 2021 Published by Elsevier Ltd on behalf of European Paediatric Neurology Societypt_PT
dc.description.abstractBackground and aims Cerebral lesions detected using cerebral ultrasound (cUS) in very preterm infants are associated with increased risk for neurodevelopmental problems. However, uncomplicated intraventricular hemorrhage (IVH) has no consistent association with poor outcome. In this study we evaluate the effect of uncomplicated IVH on estimated brain volume at term-equivalent age (TEA), using a model based on measurements made from cUS. Methods We studied 2 groups of preterm infants (<32 weeks’ gestational age (GA)) up to and at TEA: (1) infants with uncomplicated grades 2 or 3 IVH, (2) infants with consistently normal scans. Estimated cerebral volumes at TEA were calculated using a previously described model based on linear measurements and compared between the 2 groups using independent groups t-test or the Mann-Whitney test; p-value <0.05 was considered significant. Results We assessed 95 preterm infants (18 with uncomplicated IVH and 71 with normal scans). GA and birth weight were lower in infants with uncomplicated IVH (26.8/28.7weeks, p < 0.001, 944/1082g, p < 0.05, respectively); occipital-frontal circumference at TEA was smaller in the IVH infants (34.2 vs 35.3 cm, p < 0.05). However, no significant differences at TEA were found for estimated cranial volume (383/411cc3), estimated cerebral volume (337/341cc3), Levene ventricular index (13.5/12.2 mm) or thalamo-occipital distance (21.5/20.3 mm). Statistical adjustment for the lower GA in the IVH group confirmed the absence of a significant difference in the findings. Conclusions In summary, we found that estimated cerebral volume at TEA, based on measurements made at the bedside using cranial US, is not different between very preterm infants with consistently normal scans and those with uncomplicated grades 2 and 3 IVH.pt_PT
dc.description.versioninfo:eu-repo/semantics/acceptedVersionpt_PT
dc.identifier.citationEuropean Journal of Paediatric Neurology (2021)pt_PT
dc.identifier.doi10.1016/j.ejpn.2021.01.002pt_PT
dc.identifier.eissn1532-2130
dc.identifier.issn1090-3798
dc.identifier.urihttp://hdl.handle.net/10451/46118
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.ejpn-journal.com/pt_PT
dc.subjectCerebral ultrasoundpt_PT
dc.subjectNewbornpt_PT
dc.subjectPretermpt_PT
dc.subjectIntraventricular hemorrhagept_PT
dc.subjectMeasurementspt_PT
dc.titleUncomplicated intraventricular hemorrhage is not associated with lower estimated cerebral volume at term agept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleEuropean Journal of Paediatric Neurologypt_PT
person.familyNameGraca
person.givenNameAndre
person.identifier.ciencia-id4812-D995-57EB
person.identifier.orcid0000-0003-2961-0083
person.identifier.ridB-4371-2012
person.identifier.scopus-author-id36938869600
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfc00fa30-b3e7-4a24-89df-996b909267cf
relation.isAuthorOfPublication.latestForDiscoveryfc00fa30-b3e7-4a24-89df-996b909267cf

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