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Protein intake and muscle mass maintenance in patients with cancer types with high prevalence of sarcopenia: a systematic review

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dc.contributor.authorCapitão, Carolina
dc.contributor.authorCoutinho, Diana
dc.contributor.authorNeves, Pedro Miguel
dc.contributor.authorCapelas, Manuel Luís
dc.contributor.authorPimenta, Nuno
dc.contributor.authorSantos, Teresa
dc.contributor.authorMäkitie, Antti
dc.contributor.authorRavasco, Paula
dc.date.accessioned2022-04-05T11:13:46Z
dc.date.available2022-04-05T11:13:46Z
dc.date.issued2021
dc.description© The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021pt_PT
dc.description.abstractRationale: Cancer is associated with muscle wasting. However, optimal protein intake has not been determined, limiting the efficacy of nutritional interventions. This systematic review aims to assess the effect of protein intake on muscle mass of patients with cancer types with high prevalence of sarcopenia during treatment, in longitudinal studies. Methods: MEDLINE, CINAHL, and Scopus databases were searched following PRISMA guidelines. Longitudinal studies written in English, including adults with high sarcopenia prevalence cancer diagnosis, submitted to (chemo)radiotherapy, with assessment of protein intake and muscle changes during treatment, published until 4 October 2020 were included. Studies including supplementation with substances, such as n-3 fatty acids, specific amino acids, or proteins, were excluded. Study appraisal was independently conducted by two reviewers, and a qualitative research synthesis was performed. Results: Overall, 575 records were identified, of which, eight studies were included (one randomized clinical trial and seven uncontrolled before and after studies). Patients with head and neck (n = 5), lung (n = 2), and esophageal cancer (n = 1) were included, comprising a total of 554 participants. The studies presented heterogeneous methodologies, objectives, and methods to assess body composition. Overall, participant groups with a mean protein intake below 1.2 g/kg presented muscle wasting, with one exception, while those reporting a mean intake above 1.4 g/kg, maintained muscle during treatment. Conclusions: Our findings show that protein intakes below 1.2 g/kg, even when within the recommendations, have been associated with muscle wasting during treatment. Only intakes above 1.4 g/kg have been associated with muscle maintenance. High-quality research is needed to establish an optimal dose response.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSupport Care Cancer. 2022 Apr;30(4):3007-3015pt_PT
dc.identifier.doi10.1007/s00520-021-06633-8pt_PT
dc.identifier.eissn1433-7339
dc.identifier.issn0941-4355
dc.identifier.urihttp://hdl.handle.net/10451/52175
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Naturept_PT
dc.relation.publisherversionhttps://www.springer.com/journal/520pt_PT
dc.subjectBody compositionpt_PT
dc.subjectCancerpt_PT
dc.subjectMuscle wastingpt_PT
dc.subjectNutritionpt_PT
dc.subjectProtein intakept_PT
dc.titleProtein intake and muscle mass maintenance in patients with cancer types with high prevalence of sarcopenia: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3015pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage3007pt_PT
oaire.citation.titleSupportive Care in Cancerpt_PT
oaire.citation.volume30pt_PT
person.familyNameda Silva Gaspar de Areia Capitão
person.familyNamePimenta
person.familyNameRavasco
person.givenNameCarolina
person.givenNameNuno
person.givenNamePaula
person.identifier754301
person.identifier381093
person.identifier.ciencia-id741A-8A14-36F5
person.identifier.ciencia-id9A10-E335-B555
person.identifier.ciencia-id2E1E-155A-9B23
person.identifier.orcid0000-0002-4614-0549
person.identifier.orcid0000-0003-2317-9755
person.identifier.orcid0000-0002-6056-8269
person.identifier.scopus-author-id37026981100
person.identifier.scopus-author-id6602551513
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationfe3a67c7-aeb0-4951-8ed4-aa90e2e1b0e2
relation.isAuthorOfPublicationd23b5e1e-f65e-41b6-8164-7b0d5f822808
relation.isAuthorOfPublicationc44c651e-a6a4-4755-a6b6-2431eef3ea93
relation.isAuthorOfPublication.latestForDiscoveryc44c651e-a6a4-4755-a6b6-2431eef3ea93

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