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Exploring the Bioactive Properties of Hydroethanolic Cork Extracts of Quercus cerris and Quercus suber

2024-07Artigo científico Acesso aberto
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dc.contributor.authorSen, Ali Umut
dc.contributor.authorAlmeida, Daiana
dc.contributor.authorSilveira, Tayse F. F. da
dc.contributor.authorPires, Tânia S. P.
dc.contributor.authorAñibarro-Ortega, Mikel
dc.contributor.authorMandim, Filipa
dc.contributor.authorBarros, Lillian
dc.contributor.authorFerreira, Isabel C. F. R.
dc.contributor.authorPereira, Helena
dc.contributor.authorFernandes, Ângela
dc.date.accessioned2025-08-08T12:50:11Z
dc.date.available2025-08-08T12:50:11Z
dc.date.issued2024-07
dc.description.abstractThe bioactive properties of underutilized corks such as Quercus cerris cork and planted Quercus suber cork in the Eastern Mediterranean are not well-known but are crucial in developing lignocellulosic biorefineries. To assess their biological potential, hydroethanolic cork extracts of Quer- cus cerris and Quercus suber were analyzed for phenolic composition, antioxidant, antiproliferative, antimicrobial activities, and hepatoxicity, as well as NO-production inhibition. Here, we show that a mild hydroethanolic extraction of Q. cerris and Q. suber corks yielded 3% phenolic extracts. The phenolic composition was similar in both cork extracts, with phenolic acids and ellagitannins as the primary compounds. The bioactivity of hydroethanolic cork extracts from Q. cerris surpassed that of Q. suber and showed effectiveness against all cancer cell lines tested. This first comprehensive study on the bioactivities of different corks involves detailed characterizations of phenolic compounds of cork extracts using UPLC-DAD-ESI/MSn, evaluations of the antioxidant properties with TBARS and OxHLIA methods, evaluation of antiproliferative activity against gastric (AGS), lung (NCI-H460), colon (CaCo2), and breast cancer (MCF7) cell lines, as well as evaluations of hepatotoxicity and NO-production inhibition. The findings from this study will help bolster the potential of using underutilized cork-rich barks as a valuable resource in bark-based biorefineries.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSen, U.; Almeida, D.; da Silveira, T.F.F.; Pires, T.S.P.; Añibarro-Ortega, M.; Mandim, F.; Barros, L.; Ferreira, I.C.F.R.; Pereira, H.; Fernandes, Â. Exploring the Bioactive Properties of Hydroethanolic Cork Extracts of Quercus cerris and Quercus suber. Processes 2024, 12, 1579. https://doi.org/10.3390/pr12081579pt_PT
dc.identifier.doi10.3390/pr12081579pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.5/102737
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMountain Research Center
dc.relationMountain Research Center
dc.relationForest Research Centre
dc.relationNot Available
dc.relation.publisherversionhttps://www.mdpi.com/journal/processespt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectcorkpt_PT
dc.subjectQuercuspt_PT
dc.subjectantioxidantpt_PT
dc.subjectantiproliferative activitypt_PT
dc.subjectantimicrobial activitypt_PT
dc.titleExploring the Bioactive Properties of Hydroethanolic Cork Extracts of Quercus cerris and Quercus suberpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMountain Research Center
oaire.awardTitleMountain Research Center
oaire.awardTitleForest Research Centre
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00690%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0007%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00239%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F00239%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC INST 2018/CEECINST%2F00016%2F2018%2FCP1505%2FCT0008/PT
oaire.citation.issue8pt_PT
oaire.citation.startPage1579pt_PT
oaire.citation.titleProcessespt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
oaire.fundingStreamCEEC INST 2018
person.familyNameSen
person.familyNameMargarida Nunes Pereira
person.givenNameAli Umut
person.givenNameHelena
person.identifier.ciencia-idBA18-7608-8655
person.identifier.ciencia-id4317-A0D2-2E2A
person.identifier.orcid0000-0003-3734-466X
person.identifier.orcid0000-0002-5393-4443
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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